---
res:
  bibo_abstract:
  - "GABAB receptor (GBR) activation inhibits neurotransmitter release in axon terminals
    in the brain, except in medial habenula (MHb) terminals, which show robust potentiation.
    However, mechanisms underlying this enigmatic potentiation remain elusive. Here,
    we report that GBR activation on MHb terminals induces an activity-dependent transition
    from a facilitating, tonic to a depressing, phasic neurotransmitter release mode.
    This transition is accompanied by a 4.1-fold increase in readily releasable vesicle
    pool (RRP) size and a 3.5-fold increase of docked synaptic vesicles (SVs) at the
    presynaptic active zone (AZ). Strikingly, the depressing phasic release exhibits
    looser coupling distance than the tonic release. Furthermore, the tonic and phasic
    release are selectively affected by deletion of synaptoporin (SPO) and Ca\r\n
    \           <jats:sup>2+</jats:sup>\r\n            -dependent activator protein
    for secretion 2 (CAPS2), respectively. SPO modulates augmentation, the short-term
    plasticity associated with tonic release, and CAPS2 retains the increased RRP
    for initial responses in phasic response trains. The cytosolic protein CAPS2 showed
    a SV-associated distribution similar to the vesicular transmembrane protein SPO,
    and they were colocalized in the same terminals. We developed the “Flash and Freeze-fracture”
    method, and revealed the release of SPO-associated vesicles in both tonic and
    phasic modes and activity-dependent recruitment of CAPS2 to the AZ during phasic
    release, which lasted several minutes. Overall, these results indicate that GBR
    activation translocates CAPS2 to the AZ along with the fusion of CAPS2-associated
    SVs, contributing to persistency of the RRP increase. Thus, we identified structural
    and molecular mechanisms underlying tonic and phasic neurotransmitter release
    and their transition by GBR activation in MHb terminals.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Koppensteiner, Peter
      foaf_surname: Koppensteiner
      foaf_workInfoHomepage: http://www.librecat.org/personId=3B8B25A8-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-3509-1948
  - foaf_Person:
      foaf_givenName: Pradeep
      foaf_name: Bhandari, Pradeep
      foaf_surname: Bhandari
      foaf_workInfoHomepage: http://www.librecat.org/personId=45EDD1BC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-0863-4481
  - foaf_Person:
      foaf_givenName: Hüseyin C
      foaf_name: Önal, Hüseyin C
      foaf_surname: Önal
      foaf_workInfoHomepage: http://www.librecat.org/personId=4659D740-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-2771-2011
  - foaf_Person:
      foaf_givenName: Carolina
      foaf_name: Borges Merjane, Carolina
      foaf_surname: Borges Merjane
      foaf_workInfoHomepage: http://www.librecat.org/personId=4305C450-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-0005-401X
  - foaf_Person:
      foaf_givenName: Elodie
      foaf_name: Le Monnier, Elodie
      foaf_surname: Le Monnier
      foaf_workInfoHomepage: http://www.librecat.org/personId=3B59276A-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Utsa
      foaf_name: Roy, Utsa
      foaf_surname: Roy
      foaf_workInfoHomepage: http://www.librecat.org/personId=4d26cf11-5355-11ee-ae5a-eb05e255b9b2
  - foaf_Person:
      foaf_givenName: Yukihiro
      foaf_name: Nakamura, Yukihiro
      foaf_surname: Nakamura
  - foaf_Person:
      foaf_givenName: Tetsushi
      foaf_name: Sadakata, Tetsushi
      foaf_surname: Sadakata
  - foaf_Person:
      foaf_givenName: Makoto
      foaf_name: Sanbo, Makoto
      foaf_surname: Sanbo
  - foaf_Person:
      foaf_givenName: Masumi
      foaf_name: Hirabayashi, Masumi
      foaf_surname: Hirabayashi
  - foaf_Person:
      foaf_givenName: JeongSeop
      foaf_name: Rhee, JeongSeop
      foaf_surname: Rhee
  - foaf_Person:
      foaf_givenName: Nils
      foaf_name: Brose, Nils
      foaf_surname: Brose
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  - foaf_Person:
      foaf_givenName: Ryuichi
      foaf_name: Shigemoto, Ryuichi
      foaf_surname: Shigemoto
      foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8761-9444
  bibo_doi: 10.1073/pnas.2301449121
  bibo_issue: '8'
  bibo_volume: 121
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001208567300006
  dct_isPartOf:
  - http://id.crossref.org/issn/0027-8424
  - http://id.crossref.org/issn/1091-6490
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: GABAB receptors induce phasic release from medial habenula terminals
    through activity-dependent recruitment of release-ready vesicles@
  fabio_hasPubmedId: '38346189'
...