---
res:
  bibo_abstract:
  - Rotavirus genomes are distributed between 11 distinct RNA molecules, all of which
    must be selectively copackaged during virus assembly. This likely occurs through
    sequence-specific RNA interactions facilitated by the RNA chaperone NSP2. Here,
    we report that NSP2 autoregulates its chaperone activity through its C-terminal
    region (CTR) that promotes RNA–RNA interactions by limiting its helix-unwinding
    activity. Unexpectedly, structural proteomics data revealed that the CTR does
    not directly interact with RNA, while accelerating RNA release from NSP2. Cryo–electron
    microscopy reconstructions of an NSP2–RNA complex reveal a highly conserved acidic
    patch on the CTR, which is poised toward the bound RNA. Virus replication was
    abrogated by charge-disrupting mutations within the acidic patch but completely
    restored by charge-preserving mutations. Mechanistic similarities between NSP2
    and the unrelated bacterial RNA chaperone Hfq suggest that accelerating RNA dissociation
    while promoting intermolecular RNA interactions may be a widespread strategy of
    RNA chaperone recycling.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jack Peter Kelly
      foaf_name: Bravo, Jack Peter Kelly
      foaf_surname: Bravo
      foaf_workInfoHomepage: http://www.librecat.org/personId=96aecfa5-8931-11ee-af30-aa6a5d6eee0e
    orcid: 0000-0003-0456-0753
  - foaf_Person:
      foaf_givenName: Kira
      foaf_name: Bartnik, Kira
      foaf_surname: Bartnik
  - foaf_Person:
      foaf_givenName: Luca
      foaf_name: Venditti, Luca
      foaf_surname: Venditti
  - foaf_Person:
      foaf_givenName: Julia
      foaf_name: Acker, Julia
      foaf_surname: Acker
  - foaf_Person:
      foaf_givenName: Emma H.
      foaf_name: Gail, Emma H.
      foaf_surname: Gail
  - foaf_Person:
      foaf_givenName: Alice
      foaf_name: Colyer, Alice
      foaf_surname: Colyer
  - foaf_Person:
      foaf_givenName: Chen
      foaf_name: Davidovich, Chen
      foaf_surname: Davidovich
  - foaf_Person:
      foaf_givenName: Don C.
      foaf_name: Lamb, Don C.
      foaf_surname: Lamb
  - foaf_Person:
      foaf_givenName: Roman
      foaf_name: Tuma, Roman
      foaf_surname: Tuma
  - foaf_Person:
      foaf_givenName: Antonio N.
      foaf_name: Calabrese, Antonio N.
      foaf_surname: Calabrese
  - foaf_Person:
      foaf_givenName: Alexander
      foaf_name: Borodavka, Alexander
      foaf_surname: Borodavka
  bibo_doi: 10.1073/pnas.2100198118
  bibo_issue: '41'
  bibo_volume: 118
  dct_date: 2021^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0027-8424
  - http://id.crossref.org/issn/1091-6490
  dct_language: eng
  dct_publisher: Proceedings of the National Academy of Sciences@
  dct_title: Structural basis of rotavirus RNA chaperone displacement and RNA annealing@
  fabio_hasPubmedId: '34615715'
...