{"extern":1,"title":"Endocannabinoids induce lateral long term potentiation of transmitter release by stimulation of gliotransmission","publication_status":"published","status":"public","date_published":"2015-10-10T00:00:00Z","date_created":"2018-12-11T11:52:27Z","month":"10","day":"10","year":"2015","volume":25,"type":"journal_article","publisher":"Oxford University Press","abstract":[{"lang":"eng","text":"Endocannabinoids (eCBs) play key roles in brain function, acting as modulatory signals in synaptic transmission and plasticity. They are recognized as retrograde messengers that mediate long-term synaptic depression (LTD), but their ability to induce long-term potentiation (LTP) is poorly known. We show that eCBs induce the long-term enhancement of transmitter release at single hippocampal synapses through stimulation of astrocytes when coincident with postsynaptic activity. This LTP requires the coordinated activity of the 3 elements of the tripartite synapse: 1) eCB-evoked astrocyte calcium signal that stimulates glutamate release; 2) postsynaptic nitric oxide production; and 3) activation of protein kinase C and presynaptic group I metabotropic glutamate receptors, whose location at presynaptic sites was confirmed by immunoelectron microscopy. Hence, while eCBs act as retrograde signals to depress homoneuronal synapses, they serve as lateral messengers to induce LTP in distant heteroneuronal synapses through stimulation of astrocytes. Therefore, eCBs can trigger LTP through stimulation of astrocyte-neuron signaling, revealing novel cellular mechanisms of eCB effects on synaptic plasticity."}],"_id":"1514","publication":"Cerebral Cortex","quality_controlled":0,"date_updated":"2021-01-12T06:51:18Z","acknowledgement":"This work was supported by grants from Ministerio de Economia y Competitividad, Spain (MINECO; BFU2010-15832), European Union (HEALTH-F2-2007-202167), and Cajal Blue Brain to A.A. Grants from Spain (MINECO; BFU-2009-08404 and\nCSD2008-00005) to R.L. Grants from Spain (MINECO; Consolider, CSD2010-00045; Ramón y Cajal Program, RYC-2012-12014; and BFU2013-47265) to G.P. We thank Dr Atsu Aiba (Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo) for the donation of the mGluR1b rescue mice.","page":"3699 - 3712","citation":{"chicago":"Gómez Gonzalo, Marta, Marta Navarrete, Gertrudis Perea, Ana Covelo, Mario Martín Fernández, Ryuichi Shigemoto, Rafael Luján, and Alfonso Araque. “Endocannabinoids Induce Lateral Long Term Potentiation of Transmitter Release by Stimulation of Gliotransmission.” <i>Cerebral Cortex</i>. Oxford University Press, 2015. <a href=\"https://doi.org/10.1093/cercor/bhu231\">https://doi.org/10.1093/cercor/bhu231</a>.","ieee":"M. Gómez Gonzalo <i>et al.</i>, “Endocannabinoids induce lateral long term potentiation of transmitter release by stimulation of gliotransmission,” <i>Cerebral Cortex</i>, vol. 25, no. 10. Oxford University Press, pp. 3699–3712, 2015.","mla":"Gómez Gonzalo, Marta, et al. “Endocannabinoids Induce Lateral Long Term Potentiation of Transmitter Release by Stimulation of Gliotransmission.” <i>Cerebral Cortex</i>, vol. 25, no. 10, Oxford University Press, 2015, pp. 3699–712, doi:<a href=\"https://doi.org/10.1093/cercor/bhu231\">10.1093/cercor/bhu231</a>.","apa":"Gómez Gonzalo, M., Navarrete, M., Perea, G., Covelo, A., Martín Fernández, M., Shigemoto, R., … Araque, A. (2015). Endocannabinoids induce lateral long term potentiation of transmitter release by stimulation of gliotransmission. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/bhu231\">https://doi.org/10.1093/cercor/bhu231</a>","ista":"Gómez Gonzalo M, Navarrete M, Perea G, Covelo A, Martín Fernández M, Shigemoto R, Luján R, Araque A. 2015. Endocannabinoids induce lateral long term potentiation of transmitter release by stimulation of gliotransmission. Cerebral Cortex. 25(10), 3699–3712.","short":"M. Gómez Gonzalo, M. Navarrete, G. Perea, A. Covelo, M. Martín Fernández, R. Shigemoto, R. Luján, A. Araque, Cerebral Cortex 25 (2015) 3699–3712.","ama":"Gómez Gonzalo M, Navarrete M, Perea G, et al. Endocannabinoids induce lateral long term potentiation of transmitter release by stimulation of gliotransmission. <i>Cerebral Cortex</i>. 2015;25(10):3699-3712. doi:<a href=\"https://doi.org/10.1093/cercor/bhu231\">10.1093/cercor/bhu231</a>"},"intvolume":"        25","publist_id":"5663","author":[{"first_name":"Marta","full_name":"Gómez-Gonzalo, Marta","last_name":"Gómez Gonzalo"},{"first_name":"Marta","last_name":"Navarrete","full_name":"Navarrete, Marta"},{"first_name":"Gertrudis","full_name":"Perea, Gertrudis","last_name":"Perea"},{"last_name":"Covelo","full_name":"Covelo, Ana","first_name":"Ana"},{"first_name":"Mario","last_name":"Martín Fernández","full_name":"Martín-Fernández, Mario"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto"},{"first_name":"Rafael","full_name":"Luján, Rafael","last_name":"Luján"},{"last_name":"Araque","full_name":"Araque, Alfonso","first_name":"Alfonso"}],"doi":"10.1093/cercor/bhu231","issue":"10"}