{"oa":1,"keyword":["Cell Biology","Molecular Biology"],"publication":"Molecular Cell","oa_version":"Preprint","intvolume":"        81","language":[{"iso":"eng"}],"external_id":{"pmid":["33631104"]},"extern":"1","scopus_import":"1","author":[{"id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","orcid":"0000-0003-0456-0753","first_name":"Jack Peter Kelly","full_name":"Bravo, Jack Peter Kelly","last_name":"Bravo"},{"first_name":"Tyler L.","last_name":"Dangerfield","full_name":"Dangerfield, Tyler L."},{"last_name":"Taylor","full_name":"Taylor, David W.","first_name":"David W."},{"first_name":"Kenneth A.","last_name":"Johnson","full_name":"Johnson, Kenneth A."}],"citation":{"chicago":"Bravo, Jack Peter Kelly, Tyler L. Dangerfield, David W. Taylor, and Kenneth A. Johnson. “Remdesivir Is a Delayed Translocation Inhibitor of SARS-CoV-2 Replication.” <i>Molecular Cell</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.molcel.2021.01.035\">https://doi.org/10.1016/j.molcel.2021.01.035</a>.","ieee":"J. P. K. Bravo, T. L. Dangerfield, D. W. Taylor, and K. A. Johnson, “Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication,” <i>Molecular Cell</i>, vol. 81, no. 7. Elsevier, p. 1548–1552.e4, 2021.","apa":"Bravo, J. P. K., Dangerfield, T. L., Taylor, D. W., &#38; Johnson, K. A. (2021). Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. <i>Molecular Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.molcel.2021.01.035\">https://doi.org/10.1016/j.molcel.2021.01.035</a>","ama":"Bravo JPK, Dangerfield TL, Taylor DW, Johnson KA. Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. <i>Molecular Cell</i>. 2021;81(7):1548-1552.e4. doi:<a href=\"https://doi.org/10.1016/j.molcel.2021.01.035\">10.1016/j.molcel.2021.01.035</a>","mla":"Bravo, Jack Peter Kelly, et al. “Remdesivir Is a Delayed Translocation Inhibitor of SARS-CoV-2 Replication.” <i>Molecular Cell</i>, vol. 81, no. 7, Elsevier, 2021, p. 1548–1552.e4, doi:<a href=\"https://doi.org/10.1016/j.molcel.2021.01.035\">10.1016/j.molcel.2021.01.035</a>.","short":"J.P.K. Bravo, T.L. Dangerfield, D.W. Taylor, K.A. Johnson, Molecular Cell 81 (2021) 1548–1552.e4.","ista":"Bravo JPK, Dangerfield TL, Taylor DW, Johnson KA. 2021. Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. Molecular Cell. 81(7), 1548–1552.e4."},"issue":"7","publication_status":"published","doi":"10.1016/j.molcel.2021.01.035","page":"1548-1552.e4","_id":"15140","year":"2021","abstract":[{"text":"Remdesivir is a nucleoside analog approved by the US FDA for treatment of COVID-19. Here, we present a 3.9-Å-resolution cryo-EM reconstruction of a remdesivir-stalled RNA-dependent RNA polymerase complex, revealing full incorporation of 3 copies of remdesivir monophosphate (RMP) and a partially incorporated fourth RMP in the active site. The structure reveals that RMP blocks RNA translocation after incorporation of 3 bases following RMP, resulting in delayed chain termination, which can guide the rational design of improved antiviral drugs.","lang":"eng"}],"title":"Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication","article_type":"original","type":"journal_article","month":"04","article_processing_charge":"No","date_updated":"2024-06-04T06:00:56Z","pmid":1,"status":"public","publisher":"Elsevier","day":"01","quality_controlled":"1","date_created":"2024-03-20T10:42:53Z","volume":81,"publication_identifier":{"issn":["1097-2765"]},"date_published":"2021-04-01T00:00:00Z","main_file_link":[{"url":"https://doi.org/10.1101/2020.12.14.422718 ","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"}