---
res:
  bibo_abstract:
  - The genomic binding sites of the transcription factor (TF) and tumor suppressor
    p53 are unusually diverse with regard to their chromatin features, including histone
    modifications, raising the possibility that the local chromatin environment can
    contextualize p53 regulation. Here, we show that epigenetic characteristics of
    closed chromatin, such as DNA methylation, do not influence the binding of p53
    across the genome. Instead, the ability of p53 to open chromatin and activate
    its target genes is locally restricted by its cofactor Trim24. Trim24 binds to
    both p53 and unmethylated histone 3 lysine 4 (H3K4), thereby preferentially localizing
    to those p53 sites that reside in closed chromatin, whereas it is deterred from
    accessible chromatin by H3K4 methylation. The presence of Trim24 increases cell
    viability upon stress and enables p53 to affect gene expression as a function
    of the local chromatin state. These findings link H3K4 methylation to p53 function
    and illustrate how specificity in chromatin can be achieved, not by TF-intrinsic
    sensitivity to histone modifications, but by employing chromatin-sensitive cofactors
    that locally modulate TF function.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Luke
      foaf_name: Isbel, Luke
      foaf_surname: Isbel
  - foaf_Person:
      foaf_givenName: Murat
      foaf_name: Iskar, Murat
      foaf_surname: Iskar
  - foaf_Person:
      foaf_givenName: Sevi
      foaf_name: Durdu, Sevi
      foaf_surname: Durdu
  - foaf_Person:
      foaf_givenName: Joscha
      foaf_name: Weiss, Joscha
      foaf_surname: Weiss
  - foaf_Person:
      foaf_givenName: Ralph S.
      foaf_name: Grand, Ralph S.
      foaf_surname: Grand
  - foaf_Person:
      foaf_givenName: Eric
      foaf_name: Hietter-Pfeiffer, Eric
      foaf_surname: Hietter-Pfeiffer
  - foaf_Person:
      foaf_givenName: Zuzanna
      foaf_name: Kozicka, Zuzanna
      foaf_surname: Kozicka
  - foaf_Person:
      foaf_givenName: Alicia
      foaf_name: Michael, Alicia
      foaf_surname: Michael
      foaf_workInfoHomepage: http://www.librecat.org/personId=6437c950-2a03-11ee-914d-d6476dd7b75c
    orcid: 0000-0002-6080-839X
  - foaf_Person:
      foaf_givenName: Lukas
      foaf_name: Burger, Lukas
      foaf_surname: Burger
  - foaf_Person:
      foaf_givenName: Nicolas H.
      foaf_name: Thomä, Nicolas H.
      foaf_surname: Thomä
  - foaf_Person:
      foaf_givenName: Dirk
      foaf_name: Schübeler, Dirk
      foaf_surname: Schübeler
  bibo_doi: 10.1038/s41594-023-01021-8
  bibo_issue: '7'
  bibo_volume: 30
  dct_date: 2023^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1545-9993
  - http://id.crossref.org/issn/1545-9985
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_subject:
  - Molecular Biology
  - Structural Biology
  dct_title: Readout of histone methylation by Trim24 locally restricts chromatin
    opening by p53@
  fabio_hasPubmedId: '37386214'
...