{"day":"01","language":[{"iso":"eng"}],"author":[{"first_name":"Jiunn CN","last_name":"Fong","full_name":"Fong, Jiunn CN"},{"last_name":"Rogers","first_name":"Andrew","full_name":"Rogers, Andrew"},{"first_name":"Alicia Kathleen","last_name":"Michael","full_name":"Michael, Alicia Kathleen","id":"6437c950-2a03-11ee-914d-d6476dd7b75c"},{"first_name":"Nicole C","last_name":"Parsley","full_name":"Parsley, Nicole C"},{"full_name":"Cornell, William-Cole","first_name":"William-Cole","last_name":"Cornell"},{"full_name":"Lin, Yu-Cheng","last_name":"Lin","first_name":"Yu-Cheng"},{"full_name":"Singh, Praveen K","first_name":"Praveen K","last_name":"Singh"},{"last_name":"Hartmann","first_name":"Raimo","full_name":"Hartmann, Raimo"},{"last_name":"Drescher","first_name":"Knut","full_name":"Drescher, Knut"},{"full_name":"Vinogradov, Evgeny","last_name":"Vinogradov","first_name":"Evgeny"},{"full_name":"Dietrich, Lars EP","first_name":"Lars EP","last_name":"Dietrich"},{"last_name":"Partch","first_name":"Carrie L","full_name":"Partch, Carrie L"},{"last_name":"Yildiz","first_name":"Fitnat H","full_name":"Yildiz, Fitnat H"}],"main_file_link":[{"url":"https://doi.org/10.7554/eLife.26163","open_access":"1"}],"year":"2017","abstract":[{"text":"Biofilm formation is critical for the infection cycle of Vibrio cholerae. Vibrio exopolysaccharides (VPS) and the matrix proteins RbmA, Bap1 and RbmC are required for the development of biofilm architecture. We demonstrate that RbmA binds VPS directly and uses a binary structural switch within its first fibronectin type III (FnIII-1) domain to control RbmA structural dynamics and the formation of VPS-dependent higher-order structures. The structural switch in FnIII-1 regulates interactions in trans with the FnIII-2 domain, leading to open (monomeric) or closed (dimeric) interfaces. The ability of RbmA to switch between open and closed states is important for V. cholerae biofilm formation, as RbmA variants with switches that are locked in either of the two states lead to biofilms with altered architecture and structural integrity.","lang":"eng"}],"oa":1,"pmid":1,"quality_controlled":"1","volume":6,"date_published":"2017-08-01T00:00:00Z","scopus_import":"1","publication_identifier":{"issn":["2050-084X"]},"article_processing_charge":"Yes","intvolume":"         6","title":"Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms","citation":{"ista":"Fong JC, Rogers A, Michael AK, Parsley NC, Cornell W-C, Lin Y-C, Singh PK, Hartmann R, Drescher K, Vinogradov E, Dietrich LE, Partch CL, Yildiz FH. 2017. Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms. eLife. 6, 26163.","mla":"Fong, Jiunn CN, et al. “Structural Dynamics of RbmA Governs Plasticity of Vibrio Cholerae Biofilms.” <i>ELife</i>, vol. 6, 26163, eLife Sciences Publications, 2017, doi:<a href=\"https://doi.org/10.7554/elife.26163\">10.7554/elife.26163</a>.","ama":"Fong JC, Rogers A, Michael AK, et al. Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms. <i>eLife</i>. 2017;6. doi:<a href=\"https://doi.org/10.7554/elife.26163\">10.7554/elife.26163</a>","chicago":"Fong, Jiunn CN, Andrew Rogers, Alicia K. Michael, Nicole C Parsley, William-Cole Cornell, Yu-Cheng Lin, Praveen K Singh, et al. “Structural Dynamics of RbmA Governs Plasticity of Vibrio Cholerae Biofilms.” <i>ELife</i>. eLife Sciences Publications, 2017. <a href=\"https://doi.org/10.7554/elife.26163\">https://doi.org/10.7554/elife.26163</a>.","apa":"Fong, J. C., Rogers, A., Michael, A. K., Parsley, N. C., Cornell, W.-C., Lin, Y.-C., … Yildiz, F. H. (2017). Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/elife.26163\">https://doi.org/10.7554/elife.26163</a>","short":"J.C. Fong, A. Rogers, A.K. Michael, N.C. Parsley, W.-C. Cornell, Y.-C. Lin, P.K. Singh, R. Hartmann, K. Drescher, E. Vinogradov, L.E. Dietrich, C.L. Partch, F.H. Yildiz, ELife 6 (2017).","ieee":"J. C. Fong <i>et al.</i>, “Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms,” <i>eLife</i>, vol. 6. eLife Sciences Publications, 2017."},"article_number":"26163","publication":"eLife","publication_status":"published","month":"08","date_created":"2024-03-21T07:55:36Z","external_id":{"pmid":["28762945"]},"publisher":"eLife Sciences Publications","article_type":"original","keyword":["General Immunology and Microbiology","General Biochemistry","Genetics and Molecular Biology","General Medicine","General Neuroscience"],"status":"public","_id":"15154","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","date_updated":"2024-03-25T12:22:54Z","oa_version":"Published Version","doi":"10.7554/elife.26163"}