---
_id: '15156'
abstract:
- lang: eng
  text: Circadian clocks are ubiquitous timing systems that induce rhythms of biological
    activities in synchrony with night and day. In cyanobacteria, timing is generated
    by a posttranslational clock consisting of KaiA, KaiB, and KaiC proteins and a
    set of output signaling proteins, SasA and CikA, which transduce this rhythm to
    control gene expression. Here, we describe crystal and nuclear magnetic resonance
    structures of KaiB-KaiC,KaiA-KaiB-KaiC, and CikA-KaiB complexes. They reveal how
    the metamorphic properties of KaiB, a protein that adopts two distinct folds,
    and the post–adenosine triphosphate hydrolysis state of KaiC create a hub around
    which nighttime signaling events revolve, including inactivation of KaiA and reciprocal
    regulation of the mutually antagonistic signaling proteins, SasA and CikA.
article_processing_charge: No
article_type: original
author:
- first_name: Roger
  full_name: Tseng, Roger
  last_name: Tseng
- first_name: Nicolette F.
  full_name: Goularte, Nicolette F.
  last_name: Goularte
- first_name: Archana
  full_name: Chavan, Archana
  last_name: Chavan
- first_name: Jansen
  full_name: Luu, Jansen
  last_name: Luu
- first_name: Susan E.
  full_name: Cohen, Susan E.
  last_name: Cohen
- first_name: Yong-Gang
  full_name: Chang, Yong-Gang
  last_name: Chang
- first_name: Joel
  full_name: Heisler, Joel
  last_name: Heisler
- first_name: Sheng
  full_name: Li, Sheng
  last_name: Li
- first_name: Alicia Kathleen
  full_name: Michael, Alicia Kathleen
  id: 6437c950-2a03-11ee-914d-d6476dd7b75c
  last_name: Michael
- first_name: Sarvind
  full_name: Tripathi, Sarvind
  last_name: Tripathi
- first_name: Susan S.
  full_name: Golden, Susan S.
  last_name: Golden
- first_name: Andy
  full_name: LiWang, Andy
  last_name: LiWang
- first_name: Carrie L.
  full_name: Partch, Carrie L.
  last_name: Partch
citation:
  ama: Tseng R, Goularte NF, Chavan A, et al. Structural basis of the day-night transition
    in a bacterial circadian clock. <i>Science</i>. 2017;355(6330):1174-1180. doi:<a
    href="https://doi.org/10.1126/science.aag2516">10.1126/science.aag2516</a>
  apa: Tseng, R., Goularte, N. F., Chavan, A., Luu, J., Cohen, S. E., Chang, Y.-G.,
    … Partch, C. L. (2017). Structural basis of the day-night transition in a bacterial
    circadian clock. <i>Science</i>. American Association for the Advancement of Science.
    <a href="https://doi.org/10.1126/science.aag2516">https://doi.org/10.1126/science.aag2516</a>
  chicago: Tseng, Roger, Nicolette F. Goularte, Archana Chavan, Jansen Luu, Susan
    E. Cohen, Yong-Gang Chang, Joel Heisler, et al. “Structural Basis of the Day-Night
    Transition in a Bacterial Circadian Clock.” <i>Science</i>. American Association
    for the Advancement of Science, 2017. <a href="https://doi.org/10.1126/science.aag2516">https://doi.org/10.1126/science.aag2516</a>.
  ieee: R. Tseng <i>et al.</i>, “Structural basis of the day-night transition in a
    bacterial circadian clock,” <i>Science</i>, vol. 355, no. 6330. American Association
    for the Advancement of Science, pp. 1174–1180, 2017.
  ista: Tseng R, Goularte NF, Chavan A, Luu J, Cohen SE, Chang Y-G, Heisler J, Li
    S, Michael AK, Tripathi S, Golden SS, LiWang A, Partch CL. 2017. Structural basis
    of the day-night transition in a bacterial circadian clock. Science. 355(6330),
    1174–1180.
  mla: Tseng, Roger, et al. “Structural Basis of the Day-Night Transition in a Bacterial
    Circadian Clock.” <i>Science</i>, vol. 355, no. 6330, American Association for
    the Advancement of Science, 2017, pp. 1174–80, doi:<a href="https://doi.org/10.1126/science.aag2516">10.1126/science.aag2516</a>.
  short: R. Tseng, N.F. Goularte, A. Chavan, J. Luu, S.E. Cohen, Y.-G. Chang, J. Heisler,
    S. Li, A.K. Michael, S. Tripathi, S.S. Golden, A. LiWang, C.L. Partch, Science
    355 (2017) 1174–1180.
date_created: 2024-03-21T07:56:24Z
date_published: 2017-03-17T00:00:00Z
date_updated: 2024-03-25T12:16:44Z
day: '17'
doi: 10.1126/science.aag2516
extern: '1'
intvolume: '       355'
issue: '6330'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '03'
oa_version: None
page: 1174-1180
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural basis of the day-night transition in a bacterial circadian clock
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 355
year: '2017'
...