---
res:
  bibo_abstract:
  - 'Cryptochromes are evolutionarily related to the light‐dependent DNA repair enzyme
    photolyase, serving as major regulators of circadian rhythms in insects and vertebrate
    animals. There are two types of cryptochromes in the animal kingdom: <jats:italic>Drosophila</jats:italic>‐like
    CRYs that act as nonvisual photopigments linking circadian rhythms to the environmental
    light/dark cycle, and vertebrate‐like CRYs that do not appear to sense light directly,
    but control the generation of circadian rhythms by acting as transcriptional repressors.
    Some animals have both types of CRYs, while others possess only one. Cryptochromes
    have two domains, the photolyase homology region (PHR) and an extended, intrinsically
    disordered C‐terminus. While all animal CRYs share a high degree of sequence and
    structural homology in their PHR domains, the C‐termini are divergent in both
    length and sequence identity. Recently, cryptochrome function has been shown to
    extend beyond its pivotal role in circadian clocks, participating in regulation
    of the DNA damage response, cancer progression and glucocorticoid signaling, as
    well as being implicated as possible magnetoreceptors. In this review, we provide
    a historical perspective on the discovery of animal cryptochromes, examine similarities
    and differences of the two types of animal cryptochromes and explore some of the
    divergent roles for this class of proteins.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Alicia Kathleen
      foaf_name: Michael, Alicia Kathleen
      foaf_surname: Michael
      foaf_workInfoHomepage: http://www.librecat.org/personId=6437c950-2a03-11ee-914d-d6476dd7b75c
  - foaf_Person:
      foaf_givenName: Jennifer L.
      foaf_name: Fribourgh, Jennifer L.
      foaf_surname: Fribourgh
  - foaf_Person:
      foaf_givenName: Russell N.
      foaf_name: Van Gelder, Russell N.
      foaf_surname: Van Gelder
  - foaf_Person:
      foaf_givenName: Carrie L.
      foaf_name: Partch, Carrie L.
      foaf_surname: Partch
  bibo_doi: 10.1111/php.12677
  bibo_issue: '1'
  bibo_volume: 93
  dct_date: 2017^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0031-8655
  - http://id.crossref.org/issn/1751-1097
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - Physical and Theoretical Chemistry
  - General Medicine
  - Biochemistry
  dct_title: 'Animal cryptochromes: Divergent roles in light perception, circadian
    timekeeping and beyond@'
...