---
_id: '15160'
abstract:
- lang: eng
  text: The circadian clock orchestrates global changes in transcriptional regulation
    on a daily basis via the bHLH-PAS transcription factor CLOCK:BMAL1. Pathways driven
    by other bHLH-PAS transcription factors have a homologous repressor that modulates
    activity on a tissue-specific basis, but none have been identified for CLOCK:BMAL1.
    We show here that the cancer/testis antigen PASD1 fulfills this role to suppress
    circadian rhythms. PASD1 is evolutionarily related to CLOCK and interacts with
    the CLOCK:BMAL1 complex to repress transcriptional activation. Expression of PASD1
    is restricted to germline tissues in healthy individuals but can be induced in
    cells of somatic origin upon oncogenic transformation. Reducing PASD1 in human
    cancer cells significantly increases the amplitude of transcriptional oscillations
    to generate more robust circadian rhythms. Our results describe a function for
    a germline-specific protein in regulation of the circadian clock and provide a
    molecular link from oncogenic transformation to suppression of circadian rhythms.
article_processing_charge: No
article_type: original
author:
- first_name: Alicia Kathleen
  full_name: Michael, Alicia Kathleen
  id: 6437c950-2a03-11ee-914d-d6476dd7b75c
  last_name: Michael
- first_name: Stacy L.
  full_name: Harvey, Stacy L.
  last_name: Harvey
- first_name: Patrick J.
  full_name: Sammons, Patrick J.
  last_name: Sammons
- first_name: Amanda P.
  full_name: Anderson, Amanda P.
  last_name: Anderson
- first_name: Hema M.
  full_name: Kopalle, Hema M.
  last_name: Kopalle
- first_name: Alison H.
  full_name: Banham, Alison H.
  last_name: Banham
- first_name: Carrie L.
  full_name: Partch, Carrie L.
  last_name: Partch
citation:
  ama: Michael AK, Harvey SL, Sammons PJ, et al. Cancer/Testis antigen PASD1 silences
    the circadian clock. <i>Molecular Cell</i>. 2015;58(5):743-754. doi:<a href="https://doi.org/10.1016/j.molcel.2015.03.031">10.1016/j.molcel.2015.03.031</a>
  apa: Michael, A. K., Harvey, S. L., Sammons, P. J., Anderson, A. P., Kopalle, H.
    M., Banham, A. H., &#38; Partch, C. L. (2015). Cancer/Testis antigen PASD1 silences
    the circadian clock. <i>Molecular Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.molcel.2015.03.031">https://doi.org/10.1016/j.molcel.2015.03.031</a>
  chicago: Michael, Alicia K., Stacy L. Harvey, Patrick J. Sammons, Amanda P. Anderson,
    Hema M. Kopalle, Alison H. Banham, and Carrie L. Partch. “Cancer/Testis Antigen
    PASD1 Silences the Circadian Clock.” <i>Molecular Cell</i>. Elsevier, 2015. <a
    href="https://doi.org/10.1016/j.molcel.2015.03.031">https://doi.org/10.1016/j.molcel.2015.03.031</a>.
  ieee: A. K. Michael <i>et al.</i>, “Cancer/Testis antigen PASD1 silences the circadian
    clock,” <i>Molecular Cell</i>, vol. 58, no. 5. Elsevier, pp. 743–754, 2015.
  ista: Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch
    CL. 2015. Cancer/Testis antigen PASD1 silences the circadian clock. Molecular
    Cell. 58(5), 743–754.
  mla: Michael, Alicia K., et al. “Cancer/Testis Antigen PASD1 Silences the Circadian
    Clock.” <i>Molecular Cell</i>, vol. 58, no. 5, Elsevier, 2015, pp. 743–54, doi:<a
    href="https://doi.org/10.1016/j.molcel.2015.03.031">10.1016/j.molcel.2015.03.031</a>.
  short: A.K. Michael, S.L. Harvey, P.J. Sammons, A.P. Anderson, H.M. Kopalle, A.H.
    Banham, C.L. Partch, Molecular Cell 58 (2015) 743–754.
date_created: 2024-03-21T07:58:08Z
date_published: 2015-06-04T00:00:00Z
date_updated: 2024-03-25T11:52:26Z
day: '04'
doi: 10.1016/j.molcel.2015.03.031
extern: '1'
intvolume: '        58'
issue: '5'
keyword:
- Cell Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.molcel.2015.03.031
month: '06'
oa: 1
oa_version: Published Version
page: 743-754
publication: Molecular Cell
publication_identifier:
  issn:
  - 1097-2765
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cancer/Testis antigen PASD1 silences the circadian clock
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2015'
...