{"publisher":"American Society for Microbiology","issue":"4","publication_identifier":{"issn":["2150-7511"]},"year":"2021","ddc":["570"],"abstract":[{"lang":"eng","text":"Copper (Cu) is a redox-active micronutrient that is both essential and toxic. Its cellular homeostasis is critical for supporting cuproprotein maturation while avoiding excessive oxidative stress. The Cu importer CcoA is the prototype of the widespread CalT subfamily of the MFS-type transporters. Hence, understanding its molecular mechanism of function is significant. Here, we show that CcoA undergoes a thiol:disulfide oxidoreduction cycle, which is important for its Cu import activity."}],"department":[{"_id":"LeSa"}],"oa_version":"Published Version","status":"public","article_type":"original","has_accepted_license":"1","date_created":"2024-04-03T07:59:04Z","article_number":"e01567","type":"journal_article","citation":{"mla":"Khalfaoui-Hassani, Bahia, et al. “Cysteine Mutants of the Major Facilitator Superfamily-Type Transporter CcoA Provide Insight into Copper Import.” <i>MBio</i>, vol. 12, no. 4, e01567, American Society for Microbiology, 2021, doi:<a href=\"https://doi.org/10.1128/mbio.01567-21\">10.1128/mbio.01567-21</a>.","ieee":"B. Khalfaoui-Hassani, P. I. Trasnea, S. Steimle, H.-G. Koch, and F. Daldal, “Cysteine mutants of the major facilitator superfamily-type transporter CcoA provide insight into copper import,” <i>mBio</i>, vol. 12, no. 4. American Society for Microbiology, 2021.","ama":"Khalfaoui-Hassani B, Trasnea PI, Steimle S, Koch H-G, Daldal F. Cysteine mutants of the major facilitator superfamily-type transporter CcoA provide insight into copper import. <i>mBio</i>. 2021;12(4). doi:<a href=\"https://doi.org/10.1128/mbio.01567-21\">10.1128/mbio.01567-21</a>","short":"B. Khalfaoui-Hassani, P.I. Trasnea, S. Steimle, H.-G. Koch, F. Daldal, MBio 12 (2021).","ista":"Khalfaoui-Hassani B, Trasnea PI, Steimle S, Koch H-G, Daldal F. 2021. Cysteine mutants of the major facilitator superfamily-type transporter CcoA provide insight into copper import. mBio. 12(4), e01567.","apa":"Khalfaoui-Hassani, B., Trasnea, P. I., Steimle, S., Koch, H.-G., &#38; Daldal, F. (2021). Cysteine mutants of the major facilitator superfamily-type transporter CcoA provide insight into copper import. <i>MBio</i>. American Society for Microbiology. <a href=\"https://doi.org/10.1128/mbio.01567-21\">https://doi.org/10.1128/mbio.01567-21</a>","chicago":"Khalfaoui-Hassani, Bahia, Petru Iulian Trasnea, Stefan Steimle, Hans-Georg Koch, and Fevzi Daldal. “Cysteine Mutants of the Major Facilitator Superfamily-Type Transporter CcoA Provide Insight into Copper Import.” <i>MBio</i>. American Society for Microbiology, 2021. <a href=\"https://doi.org/10.1128/mbio.01567-21\">https://doi.org/10.1128/mbio.01567-21</a>."},"title":"Cysteine mutants of the major facilitator superfamily-type transporter CcoA provide insight into copper import","date_updated":"2024-04-09T10:47:16Z","month":"08","keyword":["Virology","Microbiology"],"article_processing_charge":"No","quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"        12","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa":1,"file":[{"date_updated":"2024-04-09T10:45:11Z","file_size":3383398,"creator":"dernst","content_type":"application/pdf","date_created":"2024-04-09T10:45:11Z","success":1,"checksum":"2f6a57637cb3162eaeeb155a5b031e76","file_id":"15306","relation":"main_file","access_level":"open_access","file_name":"2021_mBio_KhalfaouiHassani.pdf"}],"file_date_updated":"2024-04-09T10:45:11Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"mBio","day":"31","publication_status":"published","date_published":"2021-08-31T00:00:00Z","volume":12,"_id":"15274","doi":"10.1128/mbio.01567-21","author":[{"first_name":"Bahia","full_name":"Khalfaoui-Hassani, Bahia","last_name":"Khalfaoui-Hassani"},{"first_name":"Petru Iulian","last_name":"Trasnea","full_name":"Trasnea, Petru Iulian","id":"D560034C-10C4-11EA-ABF4-A4B43DDC885E"},{"first_name":"Stefan","last_name":"Steimle","full_name":"Steimle, Stefan"},{"first_name":"Hans-Georg","last_name":"Koch","full_name":"Koch, Hans-Georg"},{"full_name":"Daldal, Fevzi","last_name":"Daldal","first_name":"Fevzi"}],"pmid":1,"external_id":{"pmid":["34281385"]}}