---
_id: '1530'
abstract:
- lang: eng
  text: In growing cells, protein synthesis and cell growth are typically not synchronous,
    and, thus, protein concentrations vary over the cell division cycle. We have developed
    a theoretical description of genetic regulatory systems in bacteria that explicitly
    considers the cell division cycle to investigate its impact on gene expression.
    We calculate the cell-to-cell variations arising from cells being at different
    stages in the division cycle for unregulated genes and for basic regulatory mechanisms.
    These variations contribute to the extrinsic noise observed in single-cell experiments,
    and are most significant for proteins with short lifetimes. Negative autoregulation
    buffers against variation of protein concentration over the division cycle, but
    the effect is found to be relatively weak. Stronger buffering is achieved by an
    increased protein lifetime. Positive autoregulation can strongly amplify such
    variation if the parameters are set to values that lead to resonance-like behaviour.
    For cooperative positive autoregulation, the concentration variation over the
    division cycle diminishes the parameter region of bistability and modulates the
    switching times between the two stable states. The same effects are seen for a
    two-gene mutual-repression toggle switch. By contrast, an oscillatory circuit,
    the repressilator, is only weakly affected by the division cycle.
article_number: '066003'
article_processing_charge: No
author:
- first_name: Veronika
  full_name: Bierbaum, Veronika
  id: 3FD04378-F248-11E8-B48F-1D18A9856A87
  last_name: Bierbaum
- first_name: Stefan
  full_name: Klumpp, Stefan
  last_name: Klumpp
citation:
  ama: Bierbaum V, Klumpp S. Impact of the cell division cycle on gene circuits. <i>Physical
    Biology</i>. 2015;12(6). doi:<a href="https://doi.org/10.1088/1478-3975/12/6/066003">10.1088/1478-3975/12/6/066003</a>
  apa: Bierbaum, V., &#38; Klumpp, S. (2015). Impact of the cell division cycle on
    gene circuits. <i>Physical Biology</i>. IOP Publishing. <a href="https://doi.org/10.1088/1478-3975/12/6/066003">https://doi.org/10.1088/1478-3975/12/6/066003</a>
  chicago: Bierbaum, Veronika, and Stefan Klumpp. “Impact of the Cell Division Cycle
    on Gene Circuits.” <i>Physical Biology</i>. IOP Publishing, 2015. <a href="https://doi.org/10.1088/1478-3975/12/6/066003">https://doi.org/10.1088/1478-3975/12/6/066003</a>.
  ieee: V. Bierbaum and S. Klumpp, “Impact of the cell division cycle on gene circuits,”
    <i>Physical Biology</i>, vol. 12, no. 6. IOP Publishing, 2015.
  ista: Bierbaum V, Klumpp S. 2015. Impact of the cell division cycle on gene circuits.
    Physical Biology. 12(6), 066003.
  mla: Bierbaum, Veronika, and Stefan Klumpp. “Impact of the Cell Division Cycle on
    Gene Circuits.” <i>Physical Biology</i>, vol. 12, no. 6, 066003, IOP Publishing,
    2015, doi:<a href="https://doi.org/10.1088/1478-3975/12/6/066003">10.1088/1478-3975/12/6/066003</a>.
  short: V. Bierbaum, S. Klumpp, Physical Biology 12 (2015).
corr_author: '1'
date_created: 2018-12-11T11:52:33Z
date_published: 2015-09-25T00:00:00Z
date_updated: 2025-09-23T09:19:53Z
day: '25'
department:
- _id: MiSi
doi: 10.1088/1478-3975/12/6/066003
external_id:
  isi:
  - '000368186300009'
intvolume: '        12'
isi: 1
issue: '6'
language:
- iso: eng
month: '09'
oa_version: None
publication: Physical Biology
publication_status: published
publisher: IOP Publishing
publist_id: '5641'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Impact of the cell division cycle on gene circuits
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 12
year: '2015'
...