---
_id: '15301'
abstract:
- lang: eng
  text: Plant morphogenesis relies exclusively on oriented cell expansion and division.
    Nonetheless, the mechanism(s) determining division plane orientation remain elusive.
    Here, we studied tissue healing after laser-assisted wounding in roots of Arabidopsis
    thaliana and uncovered how mechanical forces stabilize and reorient the microtubule
    cytoskeleton for the orientation of cell division. We identified that root tissue
    functions as an interconnected cell matrix, with a radial gradient of tissue extendibility
    causing predictable tissue deformation after wounding. This deformation causes
    instant redirection of expansion in the surrounding cells and reorientation of
    microtubule arrays, ultimately predicting cell division orientation. Microtubules
    are destabilized under low tension, whereas stretching of cells, either through
    wounding or external aspiration, immediately induces their polymerization. The
    higher microtubule abundance in the stretched cell parts leads to the reorientation
    of microtubule arrays and, ultimately, informs cell division planes. This provides
    a long-sought mechanism for flexible re-arrangement of cell divisions by mechanical
    forces for tissue reconstruction and plant architecture.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We are thankful to Simon Gilroy, Alexander Jones, and Lieven De Veylder
  for sharing published material. We thank the Imaging & Optics and Life Science Facilities
  at IST Austria, the Biooptics facility at GMI, and the Cellular Imaging Facility
  at DBMV UNIL for providing invaluable assistance. The research leading to these
  results has received funding from the European Research Council under the European
  Union's Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 742985,
  from the FWF under the stand-alone grant P29988, and from EMBO (ALTF 253-2023).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lukas
  full_name: Hörmayer, Lukas
  id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87
  last_name: Hörmayer
  orcid: 0000-0001-8295-2926
- first_name: Juan C
  full_name: Montesinos López, Juan C
  id: 310A8E3E-F248-11E8-B48F-1D18A9856A87
  last_name: Montesinos López
  orcid: 0000-0001-9179-6099
- first_name: N
  full_name: Trozzi, N
  last_name: Trozzi
- first_name: Leonhard
  full_name: Spona, Leonhard
  id: b52391fb-f636-11ee-939c-8a8c47552e8a
  last_name: Spona
- first_name: Saiko
  full_name: Yoshida, Saiko
  id: 2E46069C-F248-11E8-B48F-1D18A9856A87
  last_name: Yoshida
- first_name: Petra
  full_name: Marhavá, Petra
  id: 44E59624-F248-11E8-B48F-1D18A9856A87
  last_name: Marhavá
- first_name: Silvia
  full_name: Caballero Mancebo, Silvia
  id: 2F1E1758-F248-11E8-B48F-1D18A9856A87
  last_name: Caballero Mancebo
  orcid: 0000-0002-5223-3346
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Y
  full_name: Dagdas, Y
  last_name: Dagdas
- first_name: M
  full_name: Majda, M
  last_name: Majda
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Hörmayer L, Montesinos López JC, Trozzi N, et al. Mechanical forces in plant
    tissue matrix orient cell divisions via microtubule stabilization. <i>Developmental
    Cell</i>. 2024;59(10):1333-1344.e4. doi:<a href="https://doi.org/10.1016/j.devcel.2024.03.009">10.1016/j.devcel.2024.03.009</a>
  apa: Hörmayer, L., Montesinos López, J. C., Trozzi, N., Spona, L., Yoshida, S.,
    Marhavá, P., … Friml, J. (2024). Mechanical forces in plant tissue matrix orient
    cell divisions via microtubule stabilization. <i>Developmental Cell</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.devcel.2024.03.009">https://doi.org/10.1016/j.devcel.2024.03.009</a>
  chicago: Hörmayer, Lukas, Juan C Montesinos López, N Trozzi, Leonhard Spona, Saiko
    Yoshida, Petra Marhavá, Silvia Caballero Mancebo, et al. “Mechanical Forces in
    Plant Tissue Matrix Orient Cell Divisions via Microtubule Stabilization.” <i>Developmental
    Cell</i>. Elsevier, 2024. <a href="https://doi.org/10.1016/j.devcel.2024.03.009">https://doi.org/10.1016/j.devcel.2024.03.009</a>.
  ieee: L. Hörmayer <i>et al.</i>, “Mechanical forces in plant tissue matrix orient
    cell divisions via microtubule stabilization,” <i>Developmental Cell</i>, vol.
    59, no. 10. Elsevier, p. 1333–1344.e4, 2024.
  ista: Hörmayer L, Montesinos López JC, Trozzi N, Spona L, Yoshida S, Marhavá P,
    Caballero Mancebo S, Benková E, Heisenberg C-PJ, Dagdas Y, Majda M, Friml J. 2024.
    Mechanical forces in plant tissue matrix orient cell divisions via microtubule
    stabilization. Developmental Cell. 59(10), 1333–1344.e4.
  mla: Hörmayer, Lukas, et al. “Mechanical Forces in Plant Tissue Matrix Orient Cell
    Divisions via Microtubule Stabilization.” <i>Developmental Cell</i>, vol. 59,
    no. 10, Elsevier, 2024, p. 1333–1344.e4, doi:<a href="https://doi.org/10.1016/j.devcel.2024.03.009">10.1016/j.devcel.2024.03.009</a>.
  short: L. Hörmayer, J.C. Montesinos López, N. Trozzi, L. Spona, S. Yoshida, P. Marhavá,
    S. Caballero Mancebo, E. Benková, C.-P.J. Heisenberg, Y. Dagdas, M. Majda, J.
    Friml, Developmental Cell 59 (2024) 1333–1344.e4.
corr_author: '1'
date_created: 2024-04-08T12:07:57Z
date_published: 2024-05-20T00:00:00Z
date_updated: 2025-09-04T13:32:08Z
day: '20'
ddc:
- '570'
department:
- _id: JiFr
- _id: EvBe
- _id: CaHe
doi: 10.1016/j.devcel.2024.03.009
ec_funded: 1
external_id:
  isi:
  - '001301584600001'
  pmid:
  - '38579717'
file:
- access_level: open_access
  checksum: 22b374fb50a40d380b7686c84258d271
  content_type: application/pdf
  creator: dernst
  date_created: 2024-08-20T11:22:16Z
  date_updated: 2024-08-20T11:22:16Z
  file_id: '17452'
  file_name: 2024_DevelopmentalCell_Hoermayer.pdf
  file_size: 5195262
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file_date_updated: 2024-08-20T11:22:16Z
has_accepted_license: '1'
intvolume: '        59'
isi: 1
issue: '10'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '05'
oa: 1
oa_version: Published Version
page: 1333-1344.e4
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742985'
  name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 262EF96E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29988
  name: RNA-directed DNA methylation in plant development
publication: Developmental Cell
publication_identifier:
  eissn:
  - 1878-1551
  issn:
  - 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/how-plants-heal-wounds/
scopus_import: '1'
status: public
title: Mechanical forces in plant tissue matrix orient cell divisions via microtubule
  stabilization
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 59
year: '2024'
...