{"acknowledgement":"We thank Emmanuel Schertzer and two reviewers for comments on this manuscript. NB thanks the European Research Council for support via the grant “HaplotypeStructure” 101055327. We would also like to give our sincere thanks to Alison Etheridge for her insight, inspiration and support over the years.","quality_controlled":"1","day":"01","abstract":[{"lang":"eng","text":"We consider how a population of N haploid individuals responds to directional selection on standing variation, with no new variation from recombination or mutation. Individuals have trait values z1,…,zN, which are drawn from a distribution ψ; the fitness of individual i is proportional to [Formula: see text] . For illustration, we consider the Laplace and Gaussian distributions, which are parametrised only by the variance V0, and show that for large N, there is a scaling limit which depends on a single parameter NV0. When selection is weak relative to drift (NV0≪1), the variance decreases exponentially at rate 1/N, and the expected ultimate gain in log fitness (scaled by V0), is just NV0, which is the same as Robertson's (1960) prediction for a sexual population. In contrast, when selection is strong relative to drift (NV0≫1), the ultimate gain can be found by approximating the establishment of alleles by a branching process in which each allele competes independently with the population mean and the fittest allele to establish is certain to fix. Then, if the probability of survival to time t∼1/V0 of an allele with value z is P(z), with mean P¯, the winning allele is the fittest of NP¯ survivors drawn from a distribution ψP/P¯. The expected ultimate change is ∼2log(1.15NV0) for a Gaussian distribution, and ∼-12log0.36NV0-log-log0.36NV0 for a Laplace distribution. This approach also predicts the variability of the process, and its dynamics; we show that in the strong selection regime, the expected genetic variance decreases as ∼t-3 at large times. We discuss how these results may be related to selection on standing variation that is spread along a linear chromosome."}],"status":"public","date_updated":"2024-05-13T08:26:23Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"intvolume":"       157","article_type":"original","external_id":{"pmid":["38643838"]},"has_accepted_license":"1","pmid":1,"volume":157,"project":[{"grant_number":"101055327","_id":"bd6958e0-d553-11ed-ba76-86eba6a76c00","name":"Understanding the evolution of continuous genomes"}],"department":[{"_id":"NiBa"}],"page":"129-137","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","full_name":"Barton, Nicholas H"},{"last_name":"Sachdeva","id":"42377A0A-F248-11E8-B48F-1D18A9856A87","full_name":"Sachdeva, Himani","first_name":"Himani"}],"language":[{"iso":"eng"}],"file_date_updated":"2024-05-13T08:22:21Z","date_published":"2024-06-01T00:00:00Z","article_processing_charge":"Yes (via OA deal)","ddc":["570"],"year":"2024","file":[{"relation":"main_file","date_updated":"2024-05-13T08:22:21Z","content_type":"application/pdf","file_size":1098292,"date_created":"2024-05-13T08:22:21Z","file_name":"2024_TheorPopulationBiology_Barton.pdf","checksum":"78f36488d24f868d5913624e9c8d88bf","creator":"dernst","file_id":"15383","success":1,"access_level":"open_access"}],"date_created":"2024-05-05T22:01:03Z","publication":"Theoretical Population Biology","citation":{"chicago":"Barton, Nicholas H, and Himani Sachdeva. “Limits to Selection on Standing Variation in an Asexual Population.” <i>Theoretical Population Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.tpb.2024.04.001\">https://doi.org/10.1016/j.tpb.2024.04.001</a>.","ieee":"N. H. Barton and H. Sachdeva, “Limits to selection on standing variation in an asexual population,” <i>Theoretical Population Biology</i>, vol. 157. Elsevier, pp. 129–137, 2024.","mla":"Barton, Nicholas H., and Himani Sachdeva. “Limits to Selection on Standing Variation in an Asexual Population.” <i>Theoretical Population Biology</i>, vol. 157, Elsevier, 2024, pp. 129–37, doi:<a href=\"https://doi.org/10.1016/j.tpb.2024.04.001\">10.1016/j.tpb.2024.04.001</a>.","ama":"Barton NH, Sachdeva H. Limits to selection on standing variation in an asexual population. <i>Theoretical Population Biology</i>. 2024;157:129-137. doi:<a href=\"https://doi.org/10.1016/j.tpb.2024.04.001\">10.1016/j.tpb.2024.04.001</a>","ista":"Barton NH, Sachdeva H. 2024. Limits to selection on standing variation in an asexual population. Theoretical Population Biology. 157, 129–137.","apa":"Barton, N. H., &#38; Sachdeva, H. (2024). Limits to selection on standing variation in an asexual population. <i>Theoretical Population Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tpb.2024.04.001\">https://doi.org/10.1016/j.tpb.2024.04.001</a>","short":"N.H. Barton, H. Sachdeva, Theoretical Population Biology 157 (2024) 129–137."},"type":"journal_article","oa_version":"Published Version","title":"Limits to selection on standing variation in an asexual population","month":"06","doi":"10.1016/j.tpb.2024.04.001","publication_identifier":{"issn":["0040-5809"],"eissn":["1096-0325"]},"_id":"15358","publication_status":"published","scopus_import":"1","oa":1,"publisher":"Elsevier"}