{"title":"Tuning synaptic strength by regulation of AMPA glutamate receptor localization","day":"01","author":[{"full_name":"Stockwell, Imogen","first_name":"Imogen","last_name":"Stockwell"},{"full_name":"Watson, Jake","first_name":"Jake","id":"63836096-4690-11EA-BD4E-32803DDC885E","orcid":"0000-0002-8698-3823","last_name":"Watson"},{"full_name":"Greger, Ingo H.","first_name":"Ingo H.","last_name":"Greger"}],"scopus_import":"1","_id":"15379","external_id":{"pmid":["38693811"]},"year":"2024","article_number":" 2400006","oa":1,"date_updated":"2024-05-13T12:34:42Z","main_file_link":[{"url":"https://doi.org/10.1002/bies.202400006","open_access":"1"}],"publisher":"Wiley","month":"05","abstract":[{"text":"Long-term potentiation (LTP) of excitatory synapses is a leading model to explain the concept of information storage in the brain. Multiple mechanisms contribute to LTP, but central amongst them is an increased sensitivity of the postsynaptic membrane to neurotransmitter release. This sensitivity is predominantly determined by the abundance and localization of AMPA-type glutamate receptors (AMPARs). A combination of AMPAR structural data, super-resolution imaging of excitatory synapses, and an abundance of electrophysiological studies are providing an ever-clearer picture of how AMPARs are recruited and organized at synaptic junctions. Here, we review the latest insights into this process, and discuss how both cytoplasmic and extracellular receptor elements cooperate to tune the AMPAR response at the hippocampal CA1 synapse.","lang":"eng"}],"date_published":"2024-05-01T00:00:00Z","doi":"10.1002/bies.202400006","quality_controlled":"1","publication_identifier":{"eissn":["1521-1878"],"issn":["0265-9247"]},"acknowledgement":"The authors thank Alexander Scrutton and James M. Krieger for comments on the manuscript. The authors also acknowledge Shraddha Nayak for help with Figure 1B design. This work was supported by grants from the Medical Research Council (MC_U105174197), the BBSRC (BB/N002113/1), and the Wellcome Trust (223194/Z/21/Z) to IHG.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"BioEssays","citation":{"mla":"Stockwell, Imogen, et al. “Tuning Synaptic Strength by Regulation of AMPA Glutamate Receptor Localization.” <i>BioEssays</i>, 2400006, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/bies.202400006\">10.1002/bies.202400006</a>.","ieee":"I. Stockwell, J. Watson, and I. H. Greger, “Tuning synaptic strength by regulation of AMPA glutamate receptor localization,” <i>BioEssays</i>. Wiley, 2024.","ama":"Stockwell I, Watson J, Greger IH. Tuning synaptic strength by regulation of AMPA glutamate receptor localization. <i>BioEssays</i>. 2024. doi:<a href=\"https://doi.org/10.1002/bies.202400006\">10.1002/bies.202400006</a>","ista":"Stockwell I, Watson J, Greger IH. 2024. Tuning synaptic strength by regulation of AMPA glutamate receptor localization. BioEssays., 2400006.","apa":"Stockwell, I., Watson, J., &#38; Greger, I. H. (2024). Tuning synaptic strength by regulation of AMPA glutamate receptor localization. <i>BioEssays</i>. Wiley. <a href=\"https://doi.org/10.1002/bies.202400006\">https://doi.org/10.1002/bies.202400006</a>","chicago":"Stockwell, Imogen, Jake Watson, and Ingo H. Greger. “Tuning Synaptic Strength by Regulation of AMPA Glutamate Receptor Localization.” <i>BioEssays</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/bies.202400006\">https://doi.org/10.1002/bies.202400006</a>.","short":"I. Stockwell, J. Watson, I.H. Greger, BioEssays (2024)."},"article_processing_charge":"Yes (in subscription journal)","publication_status":"epub_ahead","language":[{"iso":"eng"}],"oa_version":"Published Version","status":"public","date_created":"2024-05-12T22:01:02Z","article_type":"review","department":[{"_id":"PeJo"}],"pmid":1,"type":"journal_article"}