---
res:
  bibo_abstract:
  - Antibiotic resistance carries a fitness cost that must be overcome in order for
    resistance to persist over the long term. Compensatory mutations that recover
    the functional defects associated with resistance mutations have been argued to
    play a key role in overcoming the cost of resistance, but compensatory mutations
    are expected to be rare relative to generally beneficial mutations that increase
    fitness, irrespective of antibiotic resistance. Given this asymmetry, population
    genetics theory predicts that populations should adapt by compensatory mutations
    when the cost of resistance is large, whereas generally beneficial mutations should
    drive adaptation when the cost of resistance is small. We tested this prediction
    by determining the genomic mechanisms underpinning adaptation to antibiotic-free
    conditions in populations of the pathogenic bacterium Pseudomonas aeruginosa that
    carry costly antibiotic resistance mutations. Whole-genome sequencing revealed
    that populations founded by high-cost rifampicin-resistant mutants adapted via
    compensatory mutations in three genes of the RNA polymerase core enzyme, whereas
    populations founded by low-cost mutants adapted by generally beneficial mutations,
    predominantly in the quorum-sensing transcriptional regulator gene lasR. Even
    though the importance of compensatory evolution in maintaining resistance has
    been widely recognized, our study shows that the roles of general adaptation in
    maintaining resistance should not be underestimated and highlights the need to
    understand how selection at other sites in the genome influences the dynamics
    of resistance alleles in clinical settings.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Qin
      foaf_name: Qi, Qin
      foaf_surname: Qi
      foaf_workInfoHomepage: http://www.librecat.org/personId=3B22D412-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6148-2416
  - foaf_Person:
      foaf_givenName: Macarena
      foaf_name: Toll Riera, Macarena
      foaf_surname: Toll Riera
  - foaf_Person:
      foaf_givenName: Karl
      foaf_name: Heilbron, Karl
      foaf_surname: Heilbron
  - foaf_Person:
      foaf_givenName: Gail
      foaf_name: Preston, Gail
      foaf_surname: Preston
  - foaf_Person:
      foaf_givenName: R Craig
      foaf_name: Maclean, R Craig
      foaf_surname: Maclean
  bibo_doi: 10.1098/rspb.2015.2452
  bibo_issue: '1822'
  bibo_volume: 283
  dct_date: 2016^xs_gYear
  dct_identifier:
  - UT:000368441200022
  dct_language: eng
  dct_publisher: Royal Society@
  dct_title: The genomic basis of adaptation to the fitness cost of rifampicin resistance
    in Pseudomonas aeruginosa@
...