---
_id: '1553'
abstract:
- lang: eng
  text: Cell movement has essential functions in development, immunity, and cancer.
    Various cell migration patterns have been reported, but no general rule has emerged
    so far. Here, we show on the basis of experimental data in vitro and in vivo that
    cell persistence, which quantifies the straightness of trajectories, is robustly
    coupled to cell migration speed. We suggest that this universal coupling constitutes
    a generic law of cell migration, which originates in the advection of polarity
    cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis
    relies on a theoretical model that we validate by measuring the persistence of
    cells upon modulation of actin flow speeds and upon optogenetic manipulation of
    the binding of an actin regulator to actin filaments. Beyond the quantitative
    prediction of the coupling, the model yields a generic phase diagram of cellular
    trajectories, which recapitulates the full range of observed migration patterns.
article_processing_charge: No
author:
- first_name: Paolo
  full_name: Maiuri, Paolo
  last_name: Maiuri
- first_name: Jean
  full_name: Rupprecht, Jean
  last_name: Rupprecht
- first_name: Stefan
  full_name: Wieser, Stefan
  id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
  last_name: Wieser
  orcid: 0000-0002-2670-2217
- first_name: Verena
  full_name: Ruprecht, Verena
  id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
  last_name: Ruprecht
  orcid: 0000-0003-4088-8633
- first_name: Olivier
  full_name: Bénichou, Olivier
  last_name: Bénichou
- first_name: Nicolas
  full_name: Carpi, Nicolas
  last_name: Carpi
- first_name: Mathieu
  full_name: Coppey, Mathieu
  last_name: Coppey
- first_name: Simon
  full_name: De Beco, Simon
  last_name: De Beco
- first_name: Nir
  full_name: Gov, Nir
  last_name: Gov
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Carolina
  full_name: Lage Crespo, Carolina
  last_name: Lage Crespo
- first_name: Franziska
  full_name: Lautenschlaeger, Franziska
  last_name: Lautenschlaeger
- first_name: Maël
  full_name: Le Berre, Maël
  last_name: Le Berre
- first_name: Ana
  full_name: Lennon Duménil, Ana
  last_name: Lennon Duménil
- first_name: Matthew
  full_name: Raab, Matthew
  last_name: Raab
- first_name: Hawa
  full_name: Thiam, Hawa
  last_name: Thiam
- first_name: Matthieu
  full_name: Piel, Matthieu
  last_name: Piel
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Raphaël
  full_name: Voituriez, Raphaël
  last_name: Voituriez
citation:
  ama: Maiuri P, Rupprecht J, Wieser S, et al. Actin flows mediate a universal coupling
    between cell speed and cell persistence. <i>Cell</i>. 2015;161(2):374-386. doi:<a
    href="https://doi.org/10.1016/j.cell.2015.01.056">10.1016/j.cell.2015.01.056</a>
  apa: Maiuri, P., Rupprecht, J., Wieser, S., Ruprecht, V., Bénichou, O., Carpi, N.,
    … Voituriez, R. (2015). Actin flows mediate a universal coupling between cell
    speed and cell persistence. <i>Cell</i>. Cell Press. <a href="https://doi.org/10.1016/j.cell.2015.01.056">https://doi.org/10.1016/j.cell.2015.01.056</a>
  chicago: Maiuri, Paolo, Jean Rupprecht, Stefan Wieser, Verena Ruprecht, Olivier
    Bénichou, Nicolas Carpi, Mathieu Coppey, et al. “Actin Flows Mediate a Universal
    Coupling between Cell Speed and Cell Persistence.” <i>Cell</i>. Cell Press, 2015.
    <a href="https://doi.org/10.1016/j.cell.2015.01.056">https://doi.org/10.1016/j.cell.2015.01.056</a>.
  ieee: P. Maiuri <i>et al.</i>, “Actin flows mediate a universal coupling between
    cell speed and cell persistence,” <i>Cell</i>, vol. 161, no. 2. Cell Press, pp.
    374–386, 2015.
  ista: Maiuri P, Rupprecht J, Wieser S, Ruprecht V, Bénichou O, Carpi N, Coppey M,
    De Beco S, Gov N, Heisenberg C-PJ, Lage Crespo C, Lautenschlaeger F, Le Berre
    M, Lennon Duménil A, Raab M, Thiam H, Piel M, Sixt MK, Voituriez R. 2015. Actin
    flows mediate a universal coupling between cell speed and cell persistence. Cell.
    161(2), 374–386.
  mla: Maiuri, Paolo, et al. “Actin Flows Mediate a Universal Coupling between Cell
    Speed and Cell Persistence.” <i>Cell</i>, vol. 161, no. 2, Cell Press, 2015, pp.
    374–86, doi:<a href="https://doi.org/10.1016/j.cell.2015.01.056">10.1016/j.cell.2015.01.056</a>.
  short: P. Maiuri, J. Rupprecht, S. Wieser, V. Ruprecht, O. Bénichou, N. Carpi, M.
    Coppey, S. De Beco, N. Gov, C.-P.J. Heisenberg, C. Lage Crespo, F. Lautenschlaeger,
    M. Le Berre, A. Lennon Duménil, M. Raab, H. Thiam, M. Piel, M.K. Sixt, R. Voituriez,
    Cell 161 (2015) 374–386.
corr_author: '1'
date_created: 2018-12-11T11:52:41Z
date_published: 2015-04-09T00:00:00Z
date_updated: 2025-09-23T07:31:01Z
day: '09'
department:
- _id: MiSi
- _id: CaHe
doi: 10.1016/j.cell.2015.01.056
ec_funded: 1
external_id:
  isi:
  - '000352708300028'
intvolume: '       161'
isi: 1
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 374 - 386
project:
- _id: 2529486C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: T 560-B17
  name: Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281556'
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
- _id: 25ABD200-B435-11E9-9278-68D0E5697425
  grant_number: RGP0058/2011
  name: 'Cell migration in complex environments: from in vivo experiments to theoretical
    models'
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '5618'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Actin flows mediate a universal coupling between cell speed and cell persistence
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 161
year: '2015'
...