---
res:
  bibo_abstract:
  - CyclophilinAis a conserved peptidyl-prolyl cis-trans isomerase (PPIase) best known
    as the cellular receptor of the immunosuppressant cyclosporine A. Despite significant
    effort, evidence of developmental functions of cyclophilin A in non-plant systems
    has remained obscure. Mutations in a tomato (Solanum lycopersicum) cyclophilin
    A ortholog, DIAGEOTROPICA (DGT), have been shown to abolish the organogenesis
    of lateral roots; however, a mechanistic explanation of the phenotype is lacking.
    Here, we show that the dgt mutant lacks auxin maxima relevant to priming and specification
    of lateral root founder cells. DGT is expressed in shoot and root, and localizes
    to both the nucleus and cytoplasm during lateral root organogenesis. Mutation
    of ENTIRE/ IAA9, a member of the auxin-responsive Aux/IAA protein family of transcriptional
    repressors, partially restores the inability of dgt to initiate lateral root primordia
    but not the primordia outgrowth. By comparison, grafting of a wild-type scion
    restores the process of lateral root formation, consistent with participation
    of a mobile signal. Antibodies do not detect movement of the DGT protein into
    the dgt rootstock; however, experiments with radiolabeled auxin and an auxin-specific
    microelectrode demonstrate abnormal auxin fluxes. Functional studies of DGT in
    heterologous yeast and tobacco-leaf auxin-transport systems demonstrate that DGT
    negatively regulates PIN-FORMED (PIN) auxin efflux transporters by affecting their
    plasma membrane localization. Studies in tomato support complex effects of the
    dgt mutation on PIN expression level, expression domain and plasma membrane localization.
    Our data demonstrate that DGT regulates auxin transport in lateral root formation.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Ivanchenko, Maria
      foaf_surname: Ivanchenko
  - foaf_Person:
      foaf_givenName: Jinsheng
      foaf_name: Zhu, Jinsheng
      foaf_surname: Zhu
  - foaf_Person:
      foaf_givenName: Bangjun
      foaf_name: Wang, Bangjun
      foaf_surname: Wang
  - foaf_Person:
      foaf_givenName: Eva
      foaf_name: Medvecka, Eva
      foaf_surname: Medvecka
      foaf_workInfoHomepage: http://www.librecat.org/personId=298814E2-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Yunlong
      foaf_name: Du, Yunlong
      foaf_surname: Du
  - foaf_Person:
      foaf_givenName: Elisa
      foaf_name: Azzarello, Elisa
      foaf_surname: Azzarello
  - foaf_Person:
      foaf_givenName: Stefano
      foaf_name: Mancuso, Stefano
      foaf_surname: Mancuso
  - foaf_Person:
      foaf_givenName: Molly
      foaf_name: Megraw, Molly
      foaf_surname: Megraw
  - foaf_Person:
      foaf_givenName: Sergei
      foaf_name: Filichkin, Sergei
      foaf_surname: Filichkin
  - foaf_Person:
      foaf_givenName: Joseph
      foaf_name: Dubrovsky, Joseph
      foaf_surname: Dubrovsky
  - foaf_Person:
      foaf_givenName: Jirí
      foaf_name: Friml, Jirí
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  - foaf_Person:
      foaf_givenName: Markus
      foaf_name: Geisler, Markus
      foaf_surname: Geisler
  bibo_doi: 10.1242/dev.113225
  bibo_issue: '4'
  bibo_volume: 142
  dct_date: 2015^xs_gYear
  dct_identifier:
  - UT:000351697100012
  dct_language: eng
  dct_publisher: Company of Biologists@
  dct_title: The cyclophilin a DIAGEOTROPICA gene affects auxin transport in both
    root and shoot to control lateral root formation@
...