---
res:
  bibo_abstract:
  - Replication-deficient recombinant adenoviruses are potent vectors for the efficient
    transient expression of exogenous genes in resting immune cells. However, most
    leukocytes are refractory to efficient adenoviral transduction as they lack expression
    of the coxsackie/adenovirus receptor (CAR). To circumvent this obstacle, we generated
    the R26/CAG-CARΔ1StopF (where R26 is ROSA26 and CAG is CMV early enhancer/chicken
    β actin promoter) knock-in mouse line. This strain allows monitoring of in situ
    Cre recombinase activity through expression of CARΔ1. Simultaneously, CARΔ1 expression
    permits selective and highly efficient adenoviral transduction of immune cell
    populations, such as mast cells or T cells, directly ex vivo in bulk cultures
    without prior cell purification or activation. Furthermore, we show that CARΔ1
    expression dramatically improves adenoviral infection of in vitro differentiated
    conventional and plasmacytoid dendritic cells (DCs), basophils, mast cells, as
    well as Hoxb8-immortalized hematopoietic progenitor cells. This novel dual function
    mouse strain will hence be a valuable tool to rapidly dissect the function of
    specific genes in leukocyte physiology.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Klaus
      foaf_name: Heger, Klaus
      foaf_surname: Heger
  - foaf_Person:
      foaf_givenName: Maike
      foaf_name: Kober, Maike
      foaf_surname: Kober
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Rieß, David
      foaf_surname: Rieß
  - foaf_Person:
      foaf_givenName: Christoph
      foaf_name: Drees, Christoph
      foaf_surname: Drees
  - foaf_Person:
      foaf_givenName: Ingrid
      foaf_name: De Vries, Ingrid
      foaf_surname: De Vries
      foaf_workInfoHomepage: http://www.librecat.org/personId=4C7D837E-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Arianna
      foaf_name: Bertossi, Arianna
      foaf_surname: Bertossi
  - foaf_Person:
      foaf_givenName: Axel
      foaf_name: Roers, Axel
      foaf_surname: Roers
  - foaf_Person:
      foaf_givenName: Michael K
      foaf_name: Sixt, Michael K
      foaf_surname: Sixt
      foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6620-9179
  - foaf_Person:
      foaf_givenName: Marc
      foaf_name: Schmidt Supprian, Marc
      foaf_surname: Schmidt Supprian
  bibo_doi: 10.1002/eji.201545457
  bibo_issue: '6'
  bibo_volume: 45
  dct_date: 2015^xs_gYear
  dct_identifier:
  - UT:000355836500006
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: A novel Cre recombinase reporter mouse strain facilitates selective and
    efficient infection of primary immune cells with adenoviral vectors@
...