---
res:
  bibo_abstract:
  - The plant hormone auxin is a key regulator of plant growth and development. Auxin
    levels are sensed and interpreted by distinct receptor systems that activate a
    broad range of cellular responses. The Auxin-Binding Protein1 (ABP1) that has
    been identified based on its ability to bind auxin with high affinity is a prime
    candidate for the extracellular receptor responsible for mediating a range of
    auxin effects, in particular, the fast non-transcriptional ones. Contradictory
    genetic studies suggested prominent or no importance of ABP1 in many developmental
    processes. However, how crucial the role of auxin binding to ABP1 is for its functions
    has not been addressed. Here, we show that the auxin-binding pocket of ABP1 is
    essential for its gain-of-function cellular and developmental roles. In total,
    16 different abp1 mutants were prepared that possessed substitutions in the metal
    core or in the hydrophobic amino acids of the auxin-binding pocket as well as
    neutral mutations. Their analysis revealed that an intact auxin-binding pocket
    is a prerequisite for ABP1 to activate downstream components of the ABP1 signalling
    pathway, such as Rho of Plants (ROPs) and to mediate the clathrin association
    with membranes for endocytosis regulation. In planta analyses demonstrated the
    importance of the auxin binding pocket for all known ABP1-mediated postembryonic
    developmental processes, including morphology of leaf epidermal cells, root growth
    and root meristem activity, and vascular tissue differentiation. Taken together,
    these findings suggest that auxin binding to ABP1 is central to its function,
    supporting the role of ABP1 as auxin receptor.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Grones, Peter
      foaf_surname: Grones
      foaf_workInfoHomepage: http://www.librecat.org/personId=399876EC-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Xu
      foaf_name: Chen, Xu
      foaf_surname: Chen
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E5ADCAA-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Sibu
      foaf_name: Simon, Sibu
      foaf_surname: Simon
      foaf_workInfoHomepage: http://www.librecat.org/personId=4542EF9A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1998-6741
  - foaf_Person:
      foaf_givenName: Walter
      foaf_name: Kaufmann, Walter
      foaf_surname: Kaufmann
      foaf_workInfoHomepage: http://www.librecat.org/personId=3F99E422-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9735-5315
  - foaf_Person:
      foaf_givenName: Riet
      foaf_name: De Rycke, Riet
      foaf_surname: De Rycke
  - foaf_Person:
      foaf_givenName: Tomasz
      foaf_name: Nodzyński, Tomasz
      foaf_surname: Nodzyński
  - foaf_Person:
      foaf_givenName: Eva
      foaf_name: Zažímalová, Eva
      foaf_surname: Zažímalová
  - foaf_Person:
      foaf_givenName: Jirí
      foaf_name: Friml, Jirí
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  bibo_doi: 10.1093/jxb/erv177
  bibo_issue: '16'
  bibo_volume: 66
  dct_date: 2015^xs_gYear
  dct_identifier:
  - UT:000359688300017
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: Auxin-binding pocket of ABP1 is crucial for its gain-of-function cellular
    and developmental roles@
...