A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development Chen, Qian Liu, Yang Maere, Steven Lee, Eunkyoung Van Isterdael, Gert Xie, Zidian Xuan, Wei Lucas, Jessica Vassileva, Valya Kitakura, Saeko Marhavy, Peter ; https://orcid.org/0000-0001-5227-5741 Wabnik, Krzysztof T ; https://orcid.org/0000-0001-7263-0560 Geldner, Niko Benková, Eva ; https://orcid.org/0000-0002-8510-9739 Le, Jie Fukaki, Hidehiro Grotewold, Erich Li, Chuanyou Friml, Jirí ; https://orcid.org/0000-0002-8302-7596 Sack, Fred Beeckman, Tom Vanneste, Steffen ddc:580 Multiple plant developmental processes, such as lateral root development, depend on auxin distribution patterns that are in part generated by the PIN-formed family of auxin-efflux transporters. Here we propose that AUXIN RESPONSE FACTOR7 (ARF7) and the ARF7-regulated FOUR LIPS/MYB124 (FLP) transcription factors jointly form a coherent feed-forward motif that mediates the auxin-responsive PIN3 transcription in planta to steer the early steps of lateral root formation. This regulatory mechanism might endow the PIN3 circuitry with a temporal 'memory' of auxin stimuli, potentially maintaining and enhancing the robustness of the auxin flux directionality during lateral root development. The cooperative action between canonical auxin signalling and other transcription factors might constitute a general mechanism by which transcriptional auxin-sensitivity can be regulated at a tissue-specific level. Nature Publishing Group 2015 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/1574 https://research-explorer.ista.ac.at/download/1574/5085 Chen Q, Liu Y, Maere S, et al. A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development. <i>Nature Communications</i>. 2015;6. doi:<a href="https://doi.org/10.1038/ncomms9821">10.1038/ncomms9821</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms9821 info:eu-repo/semantics/altIdentifier/wos/000366295500007 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess