---
res:
  bibo_abstract:
  - 'Gene expression is controlled primarily by interactions between transcription
    factor proteins (TFs) and the regulatory DNA sequence, a process that can be captured
    well by thermodynamic models of regulation. These models, however, neglect regulatory
    crosstalk: the possibility that noncognate TFs could initiate transcription, with
    potentially disastrous effects for the cell. Here, we estimate the importance
    of crosstalk, suggest that its avoidance strongly constrains equilibrium models
    of TF binding, and propose an alternative nonequilibrium scheme that implements
    kinetic proofreading to suppress erroneous initiation. This proposal is consistent
    with the observed covalent modifications of the transcriptional apparatus and
    predicts increased noise in gene expression as a trade-off for improved specificity.
    Using information theory, we quantify this trade-off to find when optimal proofreading
    architectures are favored over their equilibrium counterparts. Such architectures
    exhibit significant super-Poisson noise at low expression in steady state.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Sarah A
      foaf_name: Cepeda Humerez, Sarah A
      foaf_surname: Cepeda Humerez
      foaf_workInfoHomepage: http://www.librecat.org/personId=3DEE19A4-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Georg
      foaf_name: Rieckh, Georg
      foaf_surname: Rieckh
      foaf_workInfoHomepage: http://www.librecat.org/personId=34DA8BD6-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Gasper
      foaf_name: Tkacik, Gasper
      foaf_surname: Tkacik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  bibo_doi: 10.1103/PhysRevLett.115.248101
  bibo_issue: '24'
  bibo_volume: 115
  dct_date: 2015^xs_gYear
  dct_identifier:
  - UT:000366106700014
  dct_language: eng
  dct_publisher: American Physical Society@
  dct_title: Stochastic proofreading mechanism alleviates crosstalk in transcriptional
    regulation@
...