---
_id: '1577'
abstract:
- lang: eng
  text: Contrary to the pattern seen in mammalian sex chromosomes, where most Y-linked
    genes have X-linked homologs, the Drosophila X and Y chromosomes appear to be
    unrelated. Most of the Y-linked genes have autosomal paralogs, so autosome-to-Y
    transposition must be the main source of Drosophila Y-linked genes. Here we show
    how these genes were acquired. We found a previously unidentified gene (flagrante
    delicto Y, FDY) that originated from a recent duplication of the autosomal gene
    vig2 to the Y chromosome of Drosophila melanogaster. Four contiguous genes were
    duplicated along with vig2, but they became pseudogenes through the accumulation
    of deletions and transposable element insertions, whereas FDY remained functional,
    acquired testis-specific expression, and now accounts for ∼20% of the vig2-like
    mRNA in testis. FDY is absent in the closest relatives of D. melanogaster, and
    DNA sequence divergence indicates that the duplication to the Y chromosome occurred
    ∼2 million years ago. Thus, FDY provides a snapshot of the early stages of the
    establishment of a Y-linked gene and demonstrates how the Drosophila Y has been
    accumulating autosomal genes.
acknowledgement: "This work was supported by grants from Conselho Nacional de Desenvolvimento
  Científico e Tecnológico (CNPq), FAPERJ, and CAPES (to A.B.C.), and National Institutes
  of Health Grant R01 GM64590 (to A.G.C. and A.B.C.).\r\nWe thank M. Vibranovski,
  C. Bergman, and the Berkeley Drosophila Genome Project for access to unpublished
  data; M. Vibranovski, R. Hoskins, S. Celniker, C. Kennedy, J. Carlson, S. Galasinski,
  B. Wakimoto, J. Yasuhara, G. Sutton, M. Kuhner, J. Felsenstein, and C. Santos for
  help in various steps of the work; and B. Bitner-Mathe, R. Ventura, the members
  of the A.B.C. and A.G.C. laboratories, and two reviewers for many valuable comments
  on the manuscript."
article_processing_charge: No
article_type: original
author:
- first_name: Antonio
  full_name: Carvalho, Antonio
  last_name: Carvalho
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
- first_name: Claudia
  full_name: Russo, Claudia
  last_name: Russo
- first_name: Bonnielin
  full_name: Swenor, Bonnielin
  last_name: Swenor
- first_name: Andrew
  full_name: Clark, Andrew
  last_name: Clark
citation:
  ama: Carvalho A, Vicoso B, Russo C, Swenor B, Clark A. Birth of a new gene on the
    Y chromosome of Drosophila melanogaster. <i>PNAS</i>. 2015;112(40):12450-12455.
    doi:<a href="https://doi.org/10.1073/pnas.1516543112">10.1073/pnas.1516543112</a>
  apa: Carvalho, A., Vicoso, B., Russo, C., Swenor, B., &#38; Clark, A. (2015). Birth
    of a new gene on the Y chromosome of Drosophila melanogaster. <i>PNAS</i>. National
    Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1516543112">https://doi.org/10.1073/pnas.1516543112</a>
  chicago: Carvalho, Antonio, Beatriz Vicoso, Claudia Russo, Bonnielin Swenor, and
    Andrew Clark. “Birth of a New Gene on the Y Chromosome of Drosophila Melanogaster.”
    <i>PNAS</i>. National Academy of Sciences, 2015. <a href="https://doi.org/10.1073/pnas.1516543112">https://doi.org/10.1073/pnas.1516543112</a>.
  ieee: A. Carvalho, B. Vicoso, C. Russo, B. Swenor, and A. Clark, “Birth of a new
    gene on the Y chromosome of Drosophila melanogaster,” <i>PNAS</i>, vol. 112, no.
    40. National Academy of Sciences, pp. 12450–12455, 2015.
  ista: Carvalho A, Vicoso B, Russo C, Swenor B, Clark A. 2015. Birth of a new gene
    on the Y chromosome of Drosophila melanogaster. PNAS. 112(40), 12450–12455.
  mla: Carvalho, Antonio, et al. “Birth of a New Gene on the Y Chromosome of Drosophila
    Melanogaster.” <i>PNAS</i>, vol. 112, no. 40, National Academy of Sciences, 2015,
    pp. 12450–55, doi:<a href="https://doi.org/10.1073/pnas.1516543112">10.1073/pnas.1516543112</a>.
  short: A. Carvalho, B. Vicoso, C. Russo, B. Swenor, A. Clark, PNAS 112 (2015) 12450–12455.
date_created: 2018-12-11T11:52:49Z
date_published: 2015-10-06T00:00:00Z
date_updated: 2026-06-18T17:49:06Z
day: '06'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1073/pnas.1516543112
external_id:
  isi:
  - '000363125400061'
  pmid:
  - '26385968'
intvolume: '       112'
isi: 1
issue: '40'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603513/
month: '10'
oa: 1
oa_version: Published Version
page: 12450 - 12455
pmid: 1
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '5594'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Birth of a new gene on the Y chromosome of Drosophila melanogaster
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 112
year: '2015'
...