{"_id":"1614","volume":112,"author":[{"first_name":"Michael","last_name":"Strüber","full_name":"Strüber, Michael"},{"first_name":"Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","full_name":"Jonas, Peter M"},{"first_name":"Marlene","last_name":"Bartos","full_name":"Bartos, Marlene"}],"pmid":1,"doi":"10.1073/pnas.1412996112","project":[{"name":"Mechanisms of transmitter release at GABAergic synapses","_id":"25C26B1E-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"P24909-B24"},{"_id":"25C0F108-B435-11E9-9278-68D0E5697425","name":"Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons","grant_number":"268548","call_identifier":"FP7"}],"external_id":{"pmid":["25583495"]},"publication_status":"published","day":"27","publication":"PNAS","date_published":"2015-01-27T00:00:00Z","file":[{"file_name":"2015_PNAS_Strueber.pdf","relation":"main_file","access_level":"open_access","file_id":"5838","checksum":"6703309a1f58493cf5a704211fb6ebed","date_created":"2019-01-17T07:52:40Z","content_type":"application/pdf","creator":"dernst","file_size":1280860,"date_updated":"2020-07-14T12:45:07Z"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"1220 - 1225","file_date_updated":"2020-07-14T12:45:07Z","publist_id":"5552","language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"       112","oa":1,"month":"01","date_updated":"2021-01-12T06:52:01Z","title":"Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells","scopus_import":1,"date_created":"2018-12-11T11:53:02Z","has_accepted_license":"1","type":"journal_article","citation":{"chicago":"Strüber, Michael, Peter M Jonas, and Marlene Bartos. “Strength and Duration of Perisomatic GABAergic Inhibition Depend on Distance between Synaptically Connected Cells.” <i>PNAS</i>. National Academy of Sciences, 2015. <a href=\"https://doi.org/10.1073/pnas.1412996112\">https://doi.org/10.1073/pnas.1412996112</a>.","apa":"Strüber, M., Jonas, P. M., &#38; Bartos, M. (2015). Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1412996112\">https://doi.org/10.1073/pnas.1412996112</a>","ista":"Strüber M, Jonas PM, Bartos M. 2015. Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells. PNAS. 112(4), 1220–1225.","short":"M. Strüber, P.M. Jonas, M. Bartos, PNAS 112 (2015) 1220–1225.","ieee":"M. Strüber, P. M. Jonas, and M. Bartos, “Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells,” <i>PNAS</i>, vol. 112, no. 4. National Academy of Sciences, pp. 1220–1225, 2015.","ama":"Strüber M, Jonas PM, Bartos M. Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells. <i>PNAS</i>. 2015;112(4):1220-1225. doi:<a href=\"https://doi.org/10.1073/pnas.1412996112\">10.1073/pnas.1412996112</a>","mla":"Strüber, Michael, et al. “Strength and Duration of Perisomatic GABAergic Inhibition Depend on Distance between Synaptically Connected Cells.” <i>PNAS</i>, vol. 112, no. 4, National Academy of Sciences, 2015, pp. 1220–25, doi:<a href=\"https://doi.org/10.1073/pnas.1412996112\">10.1073/pnas.1412996112</a>."},"department":[{"_id":"PeJo"}],"oa_version":"Published Version","status":"public","ec_funded":1,"issue":"4","publisher":"National Academy of Sciences","abstract":[{"lang":"eng","text":"GABAergic perisoma-inhibiting fast-spiking interneurons (PIIs) effectively control the activity of large neuron populations by their wide axonal arborizations. It is generally assumed that the output of one PII to its target cells is strong and rapid. Here, we show that, unexpectedly, both strength and time course of PII-mediated perisomatic inhibition change with distance between synaptically connected partners in the rodent hippocampus. Synaptic signals become weaker due to lower contact numbers and decay more slowly with distance, very likely resulting from changes in GABAA receptor subunit composition. When distance-dependent synaptic inhibition is introduced to a rhythmically active neuronal network model, randomly driven principal cell assemblies are strongly synchronized by the PIIs, leading to higher precision in principal cell spike times than in a network with uniform synaptic inhibition. "}],"ddc":["570"],"year":"2015"}