---
_id: '1614'
abstract:
- lang: eng
  text: 'GABAergic perisoma-inhibiting fast-spiking interneurons (PIIs) effectively
    control the activity of large neuron populations by their wide axonal arborizations.
    It is generally assumed that the output of one PII to its target cells is strong
    and rapid. Here, we show that, unexpectedly, both strength and time course of
    PII-mediated perisomatic inhibition change with distance between synaptically
    connected partners in the rodent hippocampus. Synaptic signals become weaker due
    to lower contact numbers and decay more slowly with distance, very likely resulting
    from changes in GABAA receptor subunit composition. When distance-dependent synaptic
    inhibition is introduced to a rhythmically active neuronal network model, randomly
    driven principal cell assemblies are strongly synchronized by the PIIs, leading
    to higher precision in principal cell spike times than in a network with uniform
    synaptic inhibition. '
article_processing_charge: No
author:
- first_name: Michael
  full_name: Strüber, Michael
  last_name: Strüber
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Marlene
  full_name: Bartos, Marlene
  last_name: Bartos
citation:
  ama: Strüber M, Jonas PM, Bartos M. Strength and duration of perisomatic GABAergic
    inhibition depend on distance between synaptically connected cells. <i>PNAS</i>.
    2015;112(4):1220-1225. doi:<a href="https://doi.org/10.1073/pnas.1412996112">10.1073/pnas.1412996112</a>
  apa: Strüber, M., Jonas, P. M., &#38; Bartos, M. (2015). Strength and duration of
    perisomatic GABAergic inhibition depend on distance between synaptically connected
    cells. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1412996112">https://doi.org/10.1073/pnas.1412996112</a>
  chicago: Strüber, Michael, Peter M Jonas, and Marlene Bartos. “Strength and Duration
    of Perisomatic GABAergic Inhibition Depend on Distance between Synaptically Connected
    Cells.” <i>PNAS</i>. National Academy of Sciences, 2015. <a href="https://doi.org/10.1073/pnas.1412996112">https://doi.org/10.1073/pnas.1412996112</a>.
  ieee: M. Strüber, P. M. Jonas, and M. Bartos, “Strength and duration of perisomatic
    GABAergic inhibition depend on distance between synaptically connected cells,”
    <i>PNAS</i>, vol. 112, no. 4. National Academy of Sciences, pp. 1220–1225, 2015.
  ista: Strüber M, Jonas PM, Bartos M. 2015. Strength and duration of perisomatic
    GABAergic inhibition depend on distance between synaptically connected cells.
    PNAS. 112(4), 1220–1225.
  mla: Strüber, Michael, et al. “Strength and Duration of Perisomatic GABAergic Inhibition
    Depend on Distance between Synaptically Connected Cells.” <i>PNAS</i>, vol. 112,
    no. 4, National Academy of Sciences, 2015, pp. 1220–25, doi:<a href="https://doi.org/10.1073/pnas.1412996112">10.1073/pnas.1412996112</a>.
  short: M. Strüber, P.M. Jonas, M. Bartos, PNAS 112 (2015) 1220–1225.
date_created: 2018-12-11T11:53:02Z
date_published: 2015-01-27T00:00:00Z
date_updated: 2025-09-23T10:49:39Z
day: '27'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1073/pnas.1412996112
ec_funded: 1
external_id:
  isi:
  - '000348417000066'
  pmid:
  - '25583495'
file:
- access_level: open_access
  checksum: 6703309a1f58493cf5a704211fb6ebed
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-17T07:52:40Z
  date_updated: 2020-07-14T12:45:07Z
  file_id: '5838'
  file_name: 2015_PNAS_Strueber.pdf
  file_size: 1280860
  relation: main_file
file_date_updated: 2020-07-14T12:45:07Z
has_accepted_license: '1'
intvolume: '       112'
isi: 1
issue: '4'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 1220 - 1225
pmid: 1
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '5552'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Strength and duration of perisomatic GABAergic inhibition depend on distance
  between synaptically connected cells
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 112
year: '2015'
...