---
res:
  bibo_abstract:
  - The hippocampus plays a key role in learning and memory. Previous studies suggested
    that the main types of principal neurons, dentate gyrus granule cells (GCs), CA3
    pyramidal neurons, and CA1 pyramidal neurons, differ in their activity pattern,
    with sparse firing in GCs and more frequent firing in CA3 and CA1 pyramidal neurons.
    It has been assumed but never shown that such different activity may be caused
    by differential synaptic excitation. To test this hypothesis, we performed high-resolution
    whole-cell patch-clamp recordings in anesthetized rats in vivo. In contrast to
    previous in vitro data, both CA3 and CA1 pyramidal neurons fired action potentials
    spontaneously, with a frequency of ∼3–6 Hz, whereas GCs were silent. Furthermore,
    both CA3 and CA1 cells primarily fired in bursts. To determine the underlying
    mechanisms, we quantitatively assessed the frequency of spontaneous excitatory
    synaptic input, the passive membrane properties, and the active membrane characteristics.
    Surprisingly, GCs showed comparable synaptic excitation to CA3 and CA1 cells and
    the highest ratio of excitation versus hyperpolarizing inhibition. Thus, differential
    synaptic excitation is not responsible for differences in firing. Moreover, the
    three types of hippocampal neurons markedly differed in their passive properties.
    While GCs showed the most negative membrane potential, CA3 pyramidal neurons had
    the highest input resistance and the slowest membrane time constant. The three
    types of neurons also differed in the active membrane characteristics. GCs showed
    the highest action potential threshold, but displayed the largest gain of the
    input-output curves. In conclusion, our results reveal that differential firing
    of the three main types of hippocampal principal neurons in vivo is not primarily
    caused by differences in the characteristics of the synaptic input, but by the
    distinct properties of synaptic integration and input-output transformation.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Janina
      foaf_name: Kowalski, Janina
      foaf_surname: Kowalski
      foaf_workInfoHomepage: http://www.librecat.org/personId=3F3CA136-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Jian
      foaf_name: Gan, Jian
      foaf_surname: Gan
      foaf_workInfoHomepage: http://www.librecat.org/personId=3614E438-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  - foaf_Person:
      foaf_givenName: Alejandro
      foaf_name: Pernia-Andrade, Alejandro
      foaf_surname: Pernia-Andrade
      foaf_workInfoHomepage: http://www.librecat.org/personId=36963E98-F248-11E8-B48F-1D18A9856A87
  bibo_doi: 10.1002/hipo.22550
  bibo_issue: '5'
  bibo_volume: 26
  dct_date: 2016^xs_gYear
  dct_identifier:
  - UT:000374666700011
  dct_isPartOf:
  - http://id.crossref.org/issn/1050-9631
  - http://id.crossref.org/issn/1098-1063
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: Intrinsic membrane properties determine hippocampal differential firing
    pattern in vivo in anesthetized rats@
...