A giant molecular proton pump: structure and mechanism of respiratory complex I

article A giant molecular proton pump: structure and mechanism of respiratory complex I published yes Leonid A Sazanov author 338D39FE-F248-11E8-B48F-1D18A9856A870000-0002-0977-7989 LeSa department The mitochondrial respiratory chain, also known as the electron transport chain (ETC), is crucial to life, and energy production in the form of ATP is the main mitochondrial function. Three proton-translocating enzymes of the ETC, namely complexes I, III and IV, generate proton motive force, which in turn drives ATP synthase (complex V). The atomic structures and basic mechanisms of most respiratory complexes have previously been established, with the exception of complex I, the largest complex in the ETC. Recently, the crystal structure of the entire complex I was solved using a bacterial enzyme. The structure provided novel insights into the core architecture of the complex, the electron transfer and proton translocation pathways, as well as the mechanism that couples these two processes. Nature Publishing Group2015 eng Nature Reviews Molecular Cell Biology 00035496090000910.1038/nrm3997 166375 - 388 Sazanov LA. 2015. A giant molecular proton pump: structure and mechanism of respiratory complex I. Nature Reviews Molecular Cell Biology. 16(6), 375–388. Sazanov, L. A. (2015). A giant molecular proton pump: structure and mechanism of respiratory complex I. Nature Reviews Molecular Cell Biology. Nature Publishing Group. <a href="https://doi.org/10.1038/nrm3997">https://doi.org/10.1038/nrm3997</a> L. A. Sazanov, “A giant molecular proton pump: structure and mechanism of respiratory complex I,” Nature Reviews Molecular Cell Biology, vol. 16, no. 6. Nature Publishing Group, pp. 375–388, 2015. Sazanov, Leonid A. “A Giant Molecular Proton Pump: Structure and Mechanism of Respiratory Complex I.” Nature Reviews Molecular Cell Biology. Nature Publishing Group, 2015. <a href="https://doi.org/10.1038/nrm3997">https://doi.org/10.1038/nrm3997</a>. Sazanov LA. A giant molecular proton pump: structure and mechanism of respiratory complex I. Nature Reviews Molecular Cell Biology. 2015;16(6):375-388. doi:<a href="https://doi.org/10.1038/nrm3997">10.1038/nrm3997</a> L.A. Sazanov, Nature Reviews Molecular Cell Biology 16 (2015) 375–388. Sazanov, Leonid A. “A Giant Molecular Proton Pump: Structure and Mechanism of Respiratory Complex I.” Nature Reviews Molecular Cell Biology, vol. 16, no. 6, Nature Publishing Group, 2015, pp. 375–88, doi:<a href="https://doi.org/10.1038/nrm3997">10.1038/nrm3997</a>. 16382018-12-11T11:53:11Z2025-09-22T14:30:27Z