---
_id: '1638'
abstract:
- lang: eng
  text: The mitochondrial respiratory chain, also known as the electron transport
    chain (ETC), is crucial to life, and energy production in the form of ATP is the
    main mitochondrial function. Three proton-translocating enzymes of the ETC, namely
    complexes I, III and IV, generate proton motive force, which in turn drives ATP
    synthase (complex V). The atomic structures and basic mechanisms of most respiratory
    complexes have previously been established, with the exception of complex I, the
    largest complex in the ETC. Recently, the crystal structure of the entire complex
    I was solved using a bacterial enzyme. The structure provided novel insights into
    the core architecture of the complex, the electron transfer and proton translocation
    pathways, as well as the mechanism that couples these two processes.
article_processing_charge: No
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
citation:
  ama: 'Sazanov LA. A giant molecular proton pump: structure and mechanism of respiratory
    complex I. <i>Nature Reviews Molecular Cell Biology</i>. 2015;16(6):375-388. doi:<a
    href="https://doi.org/10.1038/nrm3997">10.1038/nrm3997</a>'
  apa: 'Sazanov, L. A. (2015). A giant molecular proton pump: structure and mechanism
    of respiratory complex I. <i>Nature Reviews Molecular Cell Biology</i>. Nature
    Publishing Group. <a href="https://doi.org/10.1038/nrm3997">https://doi.org/10.1038/nrm3997</a>'
  chicago: 'Sazanov, Leonid A. “A Giant Molecular Proton Pump: Structure and Mechanism
    of Respiratory Complex I.” <i>Nature Reviews Molecular Cell Biology</i>. Nature
    Publishing Group, 2015. <a href="https://doi.org/10.1038/nrm3997">https://doi.org/10.1038/nrm3997</a>.'
  ieee: 'L. A. Sazanov, “A giant molecular proton pump: structure and mechanism of
    respiratory complex I,” <i>Nature Reviews Molecular Cell Biology</i>, vol. 16,
    no. 6. Nature Publishing Group, pp. 375–388, 2015.'
  ista: 'Sazanov LA. 2015. A giant molecular proton pump: structure and mechanism
    of respiratory complex I. Nature Reviews Molecular Cell Biology. 16(6), 375–388.'
  mla: 'Sazanov, Leonid A. “A Giant Molecular Proton Pump: Structure and Mechanism
    of Respiratory Complex I.” <i>Nature Reviews Molecular Cell Biology</i>, vol.
    16, no. 6, Nature Publishing Group, 2015, pp. 375–88, doi:<a href="https://doi.org/10.1038/nrm3997">10.1038/nrm3997</a>.'
  short: L.A. Sazanov, Nature Reviews Molecular Cell Biology 16 (2015) 375–388.
corr_author: '1'
date_created: 2018-12-11T11:53:11Z
date_published: 2015-05-22T00:00:00Z
date_updated: 2025-09-22T14:30:27Z
day: '22'
department:
- _id: LeSa
doi: 10.1038/nrm3997
external_id:
  isi:
  - '000354960900009'
intvolume: '        16'
isi: 1
issue: '6'
language:
- iso: eng
month: '05'
oa_version: None
page: 375 - 388
publication: Nature Reviews Molecular Cell Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '5517'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A giant molecular proton pump: structure and mechanism of respiratory complex
  I'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 16
year: '2015'
...