---
_id: '1683'
abstract:
- lang: eng
  text: The 1 MDa, 45-subunit proton-pumping NADH-ubiquinone oxidoreductase (complex
    I) is the largest complex of the mitochondrial electron transport chain. The molecular
    mechanism of complex I is central to the metabolism of cells, but has yet to be
    fully characterized. The last two years have seen steady progress towards this
    goal with the first atomic-resolution structure of the entire bacterial complex
    I, a 5 Å cryo-electron microscopy map of bovine mitochondrial complex I and a
    ∼3.8 Å resolution X-ray crystallographic study of mitochondrial complex I from
    yeast Yarrowia lipotytica. In this review we will discuss what we have learned
    from these studies and what remains to be elucidated.
article_processing_charge: No
author:
- first_name: Jame A
  full_name: Letts, Jame A
  id: 322DA418-F248-11E8-B48F-1D18A9856A87
  last_name: Letts
  orcid: 0000-0002-9864-3586
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
citation:
  ama: 'Letts JA, Sazanov LA. Gaining mass: The structure of respiratory complex I-from
    bacterial towards mitochondrial versions. <i>Current Opinion in Structural Biology</i>.
    2015;33(8):135-145. doi:<a href="https://doi.org/10.1016/j.sbi.2015.08.008">10.1016/j.sbi.2015.08.008</a>'
  apa: 'Letts, J. A., &#38; Sazanov, L. A. (2015). Gaining mass: The structure of
    respiratory complex I-from bacterial towards mitochondrial versions. <i>Current
    Opinion in Structural Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.sbi.2015.08.008">https://doi.org/10.1016/j.sbi.2015.08.008</a>'
  chicago: 'Letts, James A, and Leonid A Sazanov. “Gaining Mass: The Structure of
    Respiratory Complex I-from Bacterial towards Mitochondrial Versions.” <i>Current
    Opinion in Structural Biology</i>. Elsevier, 2015. <a href="https://doi.org/10.1016/j.sbi.2015.08.008">https://doi.org/10.1016/j.sbi.2015.08.008</a>.'
  ieee: 'J. A. Letts and L. A. Sazanov, “Gaining mass: The structure of respiratory
    complex I-from bacterial towards mitochondrial versions,” <i>Current Opinion in
    Structural Biology</i>, vol. 33, no. 8. Elsevier, pp. 135–145, 2015.'
  ista: 'Letts JA, Sazanov LA. 2015. Gaining mass: The structure of respiratory complex
    I-from bacterial towards mitochondrial versions. Current Opinion in Structural
    Biology. 33(8), 135–145.'
  mla: 'Letts, James A., and Leonid A. Sazanov. “Gaining Mass: The Structure of Respiratory
    Complex I-from Bacterial towards Mitochondrial Versions.” <i>Current Opinion in
    Structural Biology</i>, vol. 33, no. 8, Elsevier, 2015, pp. 135–45, doi:<a href="https://doi.org/10.1016/j.sbi.2015.08.008">10.1016/j.sbi.2015.08.008</a>.'
  short: J.A. Letts, L.A. Sazanov, Current Opinion in Structural Biology 33 (2015)
    135–145.
corr_author: '1'
date_created: 2018-12-11T11:53:27Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2025-09-23T08:55:19Z
day: '01'
department:
- _id: LeSa
doi: 10.1016/j.sbi.2015.08.008
external_id:
  isi:
  - '000365362400016'
intvolume: '        33'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 135 - 145
publication: Current Opinion in Structural Biology
publication_status: published
publisher: Elsevier
publist_id: '5465'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Gaining mass: The structure of respiratory complex I-from bacterial towards
  mitochondrial versions'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 33
year: '2015'
...