---
_id: '1687'
abstract:
- lang: eng
  text: Guided cell movement is essential for development and integrity of animals
    and crucially involved in cellular immune responses. Leukocytes are professional
    migratory cells that can navigate through most types of tissues and sense a wide
    range of directional cues. The responses of these cells to attractants have been
    mainly explored in tissue culture settings. How leukocytes make directional decisions
    in situ, within the challenging environment of a tissue maze, is less understood.
    Here we review recent advances in how leukocytes sense chemical cues in complex
    tissue settings and make links with paradigms of directed migration in development
    and Dictyostelium discoideum amoebae.
article_processing_charge: No
author:
- first_name: Milka
  full_name: Sarris, Milka
  last_name: Sarris
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: 'Sarris M, Sixt MK. Navigating in tissue mazes: Chemoattractant interpretation
    in complex environments. <i>Current Opinion in Cell Biology</i>. 2015;36(10):93-102.
    doi:<a href="https://doi.org/10.1016/j.ceb.2015.08.001">10.1016/j.ceb.2015.08.001</a>'
  apa: 'Sarris, M., &#38; Sixt, M. K. (2015). Navigating in tissue mazes: Chemoattractant
    interpretation in complex environments. <i>Current Opinion in Cell Biology</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.ceb.2015.08.001">https://doi.org/10.1016/j.ceb.2015.08.001</a>'
  chicago: 'Sarris, Milka, and Michael K Sixt. “Navigating in Tissue Mazes: Chemoattractant
    Interpretation in Complex Environments.” <i>Current Opinion in Cell Biology</i>.
    Elsevier, 2015. <a href="https://doi.org/10.1016/j.ceb.2015.08.001">https://doi.org/10.1016/j.ceb.2015.08.001</a>.'
  ieee: 'M. Sarris and M. K. Sixt, “Navigating in tissue mazes: Chemoattractant interpretation
    in complex environments,” <i>Current Opinion in Cell Biology</i>, vol. 36, no.
    10. Elsevier, pp. 93–102, 2015.'
  ista: 'Sarris M, Sixt MK. 2015. Navigating in tissue mazes: Chemoattractant interpretation
    in complex environments. Current Opinion in Cell Biology. 36(10), 93–102.'
  mla: 'Sarris, Milka, and Michael K. Sixt. “Navigating in Tissue Mazes: Chemoattractant
    Interpretation in Complex Environments.” <i>Current Opinion in Cell Biology</i>,
    vol. 36, no. 10, Elsevier, 2015, pp. 93–102, doi:<a href="https://doi.org/10.1016/j.ceb.2015.08.001">10.1016/j.ceb.2015.08.001</a>.'
  short: M. Sarris, M.K. Sixt, Current Opinion in Cell Biology 36 (2015) 93–102.
date_created: 2018-12-11T11:53:28Z
date_published: 2015-10-01T00:00:00Z
date_updated: 2025-09-23T09:39:11Z
day: '01'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1016/j.ceb.2015.08.001
ec_funded: 1
external_id:
  isi:
  - '000364577600014'
file:
- access_level: open_access
  checksum: c29973924b790aab02fdd91857759cfb
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:21Z
  date_updated: 2020-07-14T12:45:12Z
  file_id: '4875'
  file_name: IST-2016-445-v1+1_1-s2.0-S0955067415001064-main.pdf
  file_size: 797964
  relation: main_file
file_date_updated: 2020-07-14T12:45:12Z
has_accepted_license: '1'
intvolume: '        36'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 93 - 102
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281556'
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
publication: Current Opinion in Cell Biology
publication_status: published
publisher: Elsevier
publist_id: '5458'
pubrep_id: '445'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Navigating in tissue mazes: Chemoattractant interpretation in complex environments'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 36
year: '2015'
...