{"title":"Runaway transition in irreversible polymer condensation with cyclization","_id":"17050","year":"2024","file":[{"file_id":"17055","file_size":1409416,"date_updated":"2024-05-27T06:37:01Z","success":1,"access_level":"open_access","date_created":"2024-05-27T06:37:01Z","creator":"dernst","content_type":"application/pdf","file_name":"2024_PhysicalReviewResearch_Panoukidou.pdf","relation":"main_file","checksum":"63a962d49ef1e21a3367d265784df14b"}],"has_accepted_license":"1","acknowledgement":"D.M. acknowledges the support of the Royal Society via a University Research Fellowship. This project has received support from the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Program (Grant Agreement No. 947918 to D.M. and No. 677532 to M.L.). The authors acknowledge insightful discussions with Daan Noordermeer and Antonio Valdes, who also kindly gifted us with the 1288 plasmid.","scopus_import":"1","oa":1,"publication":"Physical Review Research","author":[{"first_name":"Maria","full_name":"Panoukidou, Maria","last_name":"Panoukidou"},{"last_name":"Weir","first_name":"Simon","full_name":"Weir, Simon"},{"first_name":"Valerio","full_name":"Sorichetti, Valerio","id":"ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b","last_name":"Sorichetti","orcid":"0000-0002-9645-6576"},{"full_name":"Fosado, Yair Gutierrez","first_name":"Yair Gutierrez","last_name":"Fosado"},{"last_name":"Lenz","first_name":"Martin","full_name":"Lenz, Martin"},{"first_name":"Davide","full_name":"Michieletto, Davide","last_name":"Michieletto"}],"abstract":[{"lang":"eng","text":"The process of polymer condensation, i.e., the formation of bonds between reactive end groups, is ubiquitous in both industry and biology. Here we study generic systems undergoing polymer condensation in competition with cyclization. Using a generalized Smoluchowski theory, molecular dynamics simulations and experiments with DNA and ATP-consuming T4 ligase, we find that this system displays a transition, from a ring-dominated regime with finite-length chains at infinite time to a linear-polymers-dominated one with chains that keep growing in time. Finally, we show that fluids prepared close to the transition may have widely different compositions and rheology at large condensation times."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":6,"type":"journal_article","language":[{"iso":"eng"}],"month":"05","date_published":"2024-05-01T00:00:00Z","quality_controlled":"1","publisher":"American Physical Society","issue":"2","article_type":"original","date_created":"2024-05-26T22:00:58Z","ddc":["530"],"doi":"10.1103/PhysRevResearch.6.023189","external_id":{"arxiv":["2210.14010"]},"department":[{"_id":"AnSa"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_identifier":{"issn":["2643-1564"]},"intvolume":"         6","citation":{"mla":"Panoukidou, Maria, et al. “Runaway Transition in Irreversible Polymer Condensation with Cyclization.” <i>Physical Review Research</i>, vol. 6, no. 2, 023189, American Physical Society, 2024, doi:<a href=\"https://doi.org/10.1103/PhysRevResearch.6.023189\">10.1103/PhysRevResearch.6.023189</a>.","apa":"Panoukidou, M., Weir, S., Sorichetti, V., Fosado, Y. G., Lenz, M., &#38; Michieletto, D. (2024). Runaway transition in irreversible polymer condensation with cyclization. <i>Physical Review Research</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevResearch.6.023189\">https://doi.org/10.1103/PhysRevResearch.6.023189</a>","ama":"Panoukidou M, Weir S, Sorichetti V, Fosado YG, Lenz M, Michieletto D. Runaway transition in irreversible polymer condensation with cyclization. <i>Physical Review Research</i>. 2024;6(2). doi:<a href=\"https://doi.org/10.1103/PhysRevResearch.6.023189\">10.1103/PhysRevResearch.6.023189</a>","ieee":"M. Panoukidou, S. Weir, V. Sorichetti, Y. G. Fosado, M. Lenz, and D. Michieletto, “Runaway transition in irreversible polymer condensation with cyclization,” <i>Physical Review Research</i>, vol. 6, no. 2. American Physical Society, 2024.","ista":"Panoukidou M, Weir S, Sorichetti V, Fosado YG, Lenz M, Michieletto D. 2024. Runaway transition in irreversible polymer condensation with cyclization. Physical Review Research. 6(2), 023189.","chicago":"Panoukidou, Maria, Simon Weir, Valerio Sorichetti, Yair Gutierrez Fosado, Martin Lenz, and Davide Michieletto. “Runaway Transition in Irreversible Polymer Condensation with Cyclization.” <i>Physical Review Research</i>. American Physical Society, 2024. <a href=\"https://doi.org/10.1103/PhysRevResearch.6.023189\">https://doi.org/10.1103/PhysRevResearch.6.023189</a>.","short":"M. Panoukidou, S. Weir, V. Sorichetti, Y.G. Fosado, M. Lenz, D. Michieletto, Physical Review Research 6 (2024)."},"article_number":"023189","status":"public","day":"01","date_updated":"2024-05-27T06:41:54Z","file_date_updated":"2024-05-27T06:37:01Z","publication_status":"published","oa_version":"Published Version","article_processing_charge":"Yes"}