---
DOAJ_listed: '1'
_id: '17050'
abstract:
- lang: eng
  text: The process of polymer condensation, i.e., the formation of bonds between
    reactive end groups, is ubiquitous in both industry and biology. Here we study
    generic systems undergoing polymer condensation in competition with cyclization.
    Using a generalized Smoluchowski theory, molecular dynamics simulations and experiments
    with DNA and ATP-consuming T4 ligase, we find that this system displays a transition,
    from a ring-dominated regime with finite-length chains at infinite time to a linear-polymers-dominated
    one with chains that keep growing in time. Finally, we show that fluids prepared
    close to the transition may have widely different compositions and rheology at
    large condensation times.
acknowledgement: D.M. acknowledges the support of the Royal Society via a University
  Research Fellowship. This project has received support from the European Research
  Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Program
  (Grant Agreement No. 947918 to D.M. and No. 677532 to M.L.). The authors acknowledge
  insightful discussions with Daan Noordermeer and Antonio Valdes, who also kindly
  gifted us with the 1288 plasmid.
article_number: '023189'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Maria
  full_name: Panoukidou, Maria
  last_name: Panoukidou
- first_name: Simon
  full_name: Weir, Simon
  last_name: Weir
- first_name: Valerio
  full_name: Sorichetti, Valerio
  id: ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
  last_name: Sorichetti
  orcid: 0000-0002-9645-6576
- first_name: Yair Gutierrez
  full_name: Fosado, Yair Gutierrez
  last_name: Fosado
- first_name: Martin
  full_name: Lenz, Martin
  last_name: Lenz
- first_name: Davide
  full_name: Michieletto, Davide
  last_name: Michieletto
citation:
  ama: Panoukidou M, Weir S, Sorichetti V, Fosado YG, Lenz M, Michieletto D. Runaway
    transition in irreversible polymer condensation with cyclization. <i>Physical
    Review Research</i>. 2024;6(2). doi:<a href="https://doi.org/10.1103/PhysRevResearch.6.023189">10.1103/PhysRevResearch.6.023189</a>
  apa: Panoukidou, M., Weir, S., Sorichetti, V., Fosado, Y. G., Lenz, M., &#38; Michieletto,
    D. (2024). Runaway transition in irreversible polymer condensation with cyclization.
    <i>Physical Review Research</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevResearch.6.023189">https://doi.org/10.1103/PhysRevResearch.6.023189</a>
  chicago: Panoukidou, Maria, Simon Weir, Valerio Sorichetti, Yair Gutierrez Fosado,
    Martin Lenz, and Davide Michieletto. “Runaway Transition in Irreversible Polymer
    Condensation with Cyclization.” <i>Physical Review Research</i>. American Physical
    Society, 2024. <a href="https://doi.org/10.1103/PhysRevResearch.6.023189">https://doi.org/10.1103/PhysRevResearch.6.023189</a>.
  ieee: M. Panoukidou, S. Weir, V. Sorichetti, Y. G. Fosado, M. Lenz, and D. Michieletto,
    “Runaway transition in irreversible polymer condensation with cyclization,” <i>Physical
    Review Research</i>, vol. 6, no. 2. American Physical Society, 2024.
  ista: Panoukidou M, Weir S, Sorichetti V, Fosado YG, Lenz M, Michieletto D. 2024.
    Runaway transition in irreversible polymer condensation with cyclization. Physical
    Review Research. 6(2), 023189.
  mla: Panoukidou, Maria, et al. “Runaway Transition in Irreversible Polymer Condensation
    with Cyclization.” <i>Physical Review Research</i>, vol. 6, no. 2, 023189, American
    Physical Society, 2024, doi:<a href="https://doi.org/10.1103/PhysRevResearch.6.023189">10.1103/PhysRevResearch.6.023189</a>.
  short: M. Panoukidou, S. Weir, V. Sorichetti, Y.G. Fosado, M. Lenz, D. Michieletto,
    Physical Review Research 6 (2024).
date_created: 2024-05-26T22:00:58Z
date_published: 2024-05-01T00:00:00Z
date_updated: 2025-05-14T09:32:40Z
day: '01'
ddc:
- '530'
department:
- _id: AnSa
doi: 10.1103/PhysRevResearch.6.023189
external_id:
  arxiv:
  - '2210.14010'
file:
- access_level: open_access
  checksum: 63a962d49ef1e21a3367d265784df14b
  content_type: application/pdf
  creator: dernst
  date_created: 2024-05-27T06:37:01Z
  date_updated: 2024-05-27T06:37:01Z
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  file_size: 1409416
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file_date_updated: 2024-05-27T06:37:01Z
has_accepted_license: '1'
intvolume: '         6'
issue: '2'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: Physical Review Research
publication_identifier:
  eissn:
  - 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Runaway transition in irreversible polymer condensation with cyclization
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2024'
...