---
res:
  bibo_abstract:
  - The collapse of polypeptides is thought important to protein folding, aggregation,
    intrinsic disorder, and phase separation. However, whether polypeptide collapse
    is modulated in cells to control protein states is unclear. Here, using integrated
    protein manipulation and imaging, we show that the chaperonin GroEL-ES can accelerate
    the folding of proteins by strengthening their collapse. GroEL induces contractile
    forces in substrate chains, which draws them into the cavity and triggers a general
    compaction and discrete folding transitions, even for slow-folding proteins. This
    collapse enhancement is strongest in the nucleotide-bound states of GroEL and
    is aided by GroES binding to the cavity rim and by the amphiphilic C-terminal
    tails at the cavity bottom. Collapse modulation is distinct from other proposed
    GroEL-ES folding acceleration mechanisms, including steric confinement and misfold
    unfolding. Given the prevalence of collapse throughout the proteome, we conjecture
    that collapse modulation is more generally relevant within the protein quality
    control machinery.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Mohsin M.
      foaf_name: Naqvi, Mohsin M.
      foaf_surname: Naqvi
  - foaf_Person:
      foaf_givenName: Mario
      foaf_name: Avellaneda Sarrió, Mario
      foaf_surname: Avellaneda Sarrió
      foaf_workInfoHomepage: http://www.librecat.org/personId=DC4BA84C-56E6-11EA-AD5D-348C3DDC885E
    orcid: 0000-0001-6406-524X
  - foaf_Person:
      foaf_givenName: Andrew
      foaf_name: Roth, Andrew
      foaf_surname: Roth
  - foaf_Person:
      foaf_givenName: Eline J.
      foaf_name: Koers, Eline J.
      foaf_surname: Koers
  - foaf_Person:
      foaf_givenName: Antoine
      foaf_name: Roland, Antoine
      foaf_surname: Roland
  - foaf_Person:
      foaf_givenName: Vanda
      foaf_name: Sunderlikova, Vanda
      foaf_surname: Sunderlikova
  - foaf_Person:
      foaf_givenName: Günter
      foaf_name: Kramer, Günter
      foaf_surname: Kramer
  - foaf_Person:
      foaf_givenName: Hays S.
      foaf_name: Rye, Hays S.
      foaf_surname: Rye
  - foaf_Person:
      foaf_givenName: Sander J.
      foaf_name: Tans, Sander J.
      foaf_surname: Tans
  bibo_doi: 10.1126/sciadv.abl6293
  bibo_issue: '9'
  bibo_volume: 8
  dct_date: 2022^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2375-2548
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: Protein chain collapse modulation and folding stimulation by GroEL-ES@
  fabio_hasPubmedId: '35245117'
...