---
res:
  bibo_abstract:
  - "Introduction: The levels of many blood proteins are associated with Alzheimer's
    disease (AD) or its pathological hallmarks. Elucidating the molecular factors
    that control circulating levels of these proteins may help to identify proteins
    associated with disease risk mechanisms.\r\n\r\nMethods: Genome-wide and epigenome-wide
    studies (nindividuals ≤1064) were performed on plasma levels of 282 AD-associated
    proteins, identified by a structured literature review. Bayesian penalized regression
    estimated contributions of genetic and epigenetic variation toward inter-individual
    differences in plasma protein levels. Mendelian randomization (MR) and co-localization
    tested associations between proteins and disease-related phenotypes.\r\n\r\nResults:
    Sixty-four independent genetic and 26 epigenetic loci were associated with 45
    proteins. Novel findings included an association between plasma triggering receptor
    expressed on myeloid cells 2 (TREM2) levels and a polymorphism and cytosine-phosphate-guanine
    (CpG) site within the MS4A4A locus. Higher plasma tubulin-specific chaperone A
    (TBCA) and TREM2 levels were significantly associated with lower AD risk.\r\n\r\nDiscussion:
    Our data inform the regulation of biomarker levels and their relationships with
    AD.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Robert F.
      foaf_name: Hillary, Robert F.
      foaf_surname: Hillary
  - foaf_Person:
      foaf_givenName: Danni A.
      foaf_name: Gadd, Danni A.
      foaf_surname: Gadd
  - foaf_Person:
      foaf_givenName: Daniel L.
      foaf_name: McCartney, Daniel L.
      foaf_surname: McCartney
  - foaf_Person:
      foaf_givenName: Liu
      foaf_name: Shi, Liu
      foaf_surname: Shi
  - foaf_Person:
      foaf_givenName: Archie
      foaf_name: Campbell, Archie
      foaf_surname: Campbell
  - foaf_Person:
      foaf_givenName: Rosie M.
      foaf_name: Walker, Rosie M.
      foaf_surname: Walker
  - foaf_Person:
      foaf_givenName: Craig W.
      foaf_name: Ritchie, Craig W.
      foaf_surname: Ritchie
  - foaf_Person:
      foaf_givenName: Ian J.
      foaf_name: Deary, Ian J.
      foaf_surname: Deary
  - foaf_Person:
      foaf_givenName: Kathryn L.
      foaf_name: Evans, Kathryn L.
      foaf_surname: Evans
  - foaf_Person:
      foaf_givenName: Alejo J.
      foaf_name: Nevado‐Holgado, Alejo J.
      foaf_surname: Nevado‐Holgado
  - foaf_Person:
      foaf_givenName: Caroline
      foaf_name: Hayward, Caroline
      foaf_surname: Hayward
  - foaf_Person:
      foaf_givenName: David J.
      foaf_name: Porteous, David J.
      foaf_surname: Porteous
  - foaf_Person:
      foaf_givenName: Andrew M.
      foaf_name: McIntosh, Andrew M.
      foaf_surname: McIntosh
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Lovestone, Simon
      foaf_surname: Lovestone
  - foaf_Person:
      foaf_givenName: Matthew Richard
      foaf_name: Robinson, Matthew Richard
      foaf_surname: Robinson
      foaf_workInfoHomepage: http://www.librecat.org/personId=E5D42276-F5DA-11E9-8E24-6303E6697425
    orcid: 0000-0001-8982-8813
  - foaf_Person:
      foaf_givenName: Riccardo E.
      foaf_name: Marioni, Riccardo E.
      foaf_surname: Marioni
  bibo_doi: 10.1002/dad2.12280
  bibo_issue: '1'
  bibo_volume: 14
  dct_date: 2022^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2352-8729
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: Genome‐ and epigenome‐wide studies of plasma protein biomarkers for Alzheimer's
    disease implicate TBCA and TREM2 in disease risk@
  fabio_hasPubmedId: '35475137'
...