{"file":[{"date_created":"2024-07-31T11:20:58Z","checksum":"b1e78c60e371f87bdf43970f17d1cb0b","content_type":"application/pdf","file_id":"17355","success":1,"creator":"dernst","file_name":"2023_ChemSystemsChem_Dass.pdf","file_size":860679,"date_updated":"2024-07-31T11:20:58Z","relation":"main_file","access_level":"open_access"}],"publication":"ChemSystemsChem","intvolume":"         5","issue":"1","department":[{"_id":"NMR"}],"title":"RNA oligomerisation without added catalyst from 2′,3′‐cyclic nucleotides by drying at air-water interfaces","oa":1,"acknowledgement":"We would like to thank Ulrich Gerland, Tobias Göppel, Joachim Rosenberger and Bernhard Altaner for their helpful remarks and discussions; Thomas Matreux, Alexandra Kühnlein, Noël Yeh Martin and Maximilian Weingart for comments on the manuscript. The authors thank J. Kussmann (LMU Munich) for providing a development version of the FermiONs++ program package. Financial support was provided by the European Research Council (ERC Evotrap, grant no. 787356, the Simons Foundation (grant no. 327125), the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project-ID 364653263 – TRR 235 (CRC 235), the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy – EXC-2094 – 390783311, and the Center for NanoScience. Open Access funding enabled and organized by Projekt DEAL.","quality_controlled":"1","file_date_updated":"2024-07-31T11:20:58Z","article_processing_charge":"Yes (via OA deal)","day":"01","language":[{"iso":"eng"}],"article_number":"e202200026","article_type":"original","_id":"17078","volume":5,"author":[{"first_name":"Avinash Vicholous","full_name":"Dass, Avinash Vicholous","last_name":"Dass"},{"first_name":"Sreekar","full_name":"Wunnava, Sreekar","last_name":"Wunnava"},{"last_name":"Langlais","full_name":"Langlais, Juliette","first_name":"Juliette"},{"first_name":"Beatriz","full_name":"von der Esch, Beatriz","last_name":"von der Esch"},{"full_name":"Krusche, Maik","last_name":"Krusche","first_name":"Maik"},{"last_name":"Ufer","full_name":"Ufer, Lennard","first_name":"Lennard"},{"full_name":"Chrisam, Nico","last_name":"Chrisam","first_name":"Nico"},{"first_name":"Romeo C. A.","last_name":"Dubini","full_name":"Dubini, Romeo C. A."},{"full_name":"Gartner, Florian","last_name":"Gartner","first_name":"Florian"},{"full_name":"Angerpointner, Severin","last_name":"Angerpointner","first_name":"Severin"},{"first_name":"Christina F.","full_name":"Dirscherl, Christina F.","last_name":"Dirscherl"},{"full_name":"Rovo, Petra","id":"c316e53f-b965-11eb-b128-bb26acc59c00","last_name":"Rovo","first_name":"Petra","orcid":"0000-0001-8729-7326"},{"last_name":"Mast","full_name":"Mast, Christof B.","first_name":"Christof B."},{"first_name":"Judit E.","full_name":"Šponer, Judit E.","last_name":"Šponer"},{"first_name":"Christian","last_name":"Ochsenfeld","full_name":"Ochsenfeld, Christian"},{"first_name":"Erwin","full_name":"Frey, Erwin","last_name":"Frey"},{"full_name":"Braun, Dieter","last_name":"Braun","first_name":"Dieter"}],"type":"journal_article","citation":{"short":"A.V. Dass, S. Wunnava, J. Langlais, B. von der Esch, M. Krusche, L. Ufer, N. Chrisam, R.C.A. Dubini, F. Gartner, S. Angerpointner, C.F. Dirscherl, P. Rovo, C.B. Mast, J.E. Šponer, C. Ochsenfeld, E. Frey, D. Braun, ChemSystemsChem 5 (2023).","apa":"Dass, A. V., Wunnava, S., Langlais, J., von der Esch, B., Krusche, M., Ufer, L., … Braun, D. (2023). RNA oligomerisation without added catalyst from 2′,3′‐cyclic nucleotides by drying at air-water interfaces. <i>ChemSystemsChem</i>. Wiley. <a href=\"https://doi.org/10.1002/syst.202200026\">https://doi.org/10.1002/syst.202200026</a>","ieee":"A. V. Dass <i>et al.</i>, “RNA oligomerisation without added catalyst from 2′,3′‐cyclic nucleotides by drying at air-water interfaces,” <i>ChemSystemsChem</i>, vol. 5, no. 1. Wiley, 2023.","mla":"Dass, Avinash Vicholous, et al. “RNA Oligomerisation without Added Catalyst from 2′,3′‐cyclic Nucleotides by Drying at Air-Water Interfaces.” <i>ChemSystemsChem</i>, vol. 5, no. 1, e202200026, Wiley, 2023, doi:<a href=\"https://doi.org/10.1002/syst.202200026\">10.1002/syst.202200026</a>.","ista":"Dass AV, Wunnava S, Langlais J, von der Esch B, Krusche M, Ufer L, Chrisam N, Dubini RCA, Gartner F, Angerpointner S, Dirscherl CF, Rovo P, Mast CB, Šponer JE, Ochsenfeld C, Frey E, Braun D. 2023. RNA oligomerisation without added catalyst from 2′,3′‐cyclic nucleotides by drying at air-water interfaces. ChemSystemsChem. 5(1), e202200026.","ama":"Dass AV, Wunnava S, Langlais J, et al. RNA oligomerisation without added catalyst from 2′,3′‐cyclic nucleotides by drying at air-water interfaces. <i>ChemSystemsChem</i>. 2023;5(1). doi:<a href=\"https://doi.org/10.1002/syst.202200026\">10.1002/syst.202200026</a>","chicago":"Dass, Avinash Vicholous, Sreekar Wunnava, Juliette Langlais, Beatriz von der Esch, Maik Krusche, Lennard Ufer, Nico Chrisam, et al. “RNA Oligomerisation without Added Catalyst from 2′,3′‐cyclic Nucleotides by Drying at Air-Water Interfaces.” <i>ChemSystemsChem</i>. Wiley, 2023. <a href=\"https://doi.org/10.1002/syst.202200026\">https://doi.org/10.1002/syst.202200026</a>."},"scopus_import":"1","doi":"10.1002/syst.202200026","month":"01","abstract":[{"text":"For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step. We found that in alkaline, drying conditions in bulk and at heated air‐water interfaces, 2′,3′‐cyclic nucleotides oligomerised without additional catalyst, forming up to 10‐mers within a day. The oligomerisation proceeded at a pH range of 7–12, at temperatures between 40–80 °C and was marginally enhanced by K<jats:sup>+</jats:sup> ions. Among the canonical ribonucleotides, cGMP oligomerised most efficiently. Quantification was performed using HPLC coupled to ESI‐TOF by fitting the isotope distribution to the mass spectra. Our study suggests a oligomerisation mechanism where cGMP aids the incorporation of the relatively unreactive nucleotides C, A and U. The 2′,3′‐cyclic ribonucleotides are byproducts of prebiotic phosphorylation, nucleotide syntheses and RNA hydrolysis, indicating direct recycling pathways. The simple reaction condition offers a plausible entry point for RNA to the evolution of life on early Earth.","lang":"eng"}],"year":"2023","date_updated":"2024-07-31T11:23:06Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["530"],"oa_version":"Published Version","publisher":"Wiley","publication_identifier":{"issn":["2570-4206","2570-4206"]},"has_accepted_license":"1","status":"public","date_created":"2024-05-29T06:13:48Z","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)"},"publication_status":"published","date_published":"2023-01-01T00:00:00Z"}