{"acknowledgement":"We would like to thank J. Maiwald for her assistance in animal behavior training, experiments, and brain slice preparation; D. Koch for her assistance in recording drive building and brain slicing; K. Kaefer and J. Wallenschus (IST Austria) for their initial technical support; S. Mikulovich for her comments on an early version of the manuscript; C. Reichert for his comments on SVM analyses; and J. Pakan for English proofreading. This project is funded by the DFG (CRC 779 and CRC 1436).","intvolume":"        43","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"date_updated":"2024-06-03T07:13:47Z","abstract":[{"lang":"eng","text":"How the coordination of neuronal spiking and brain rhythms between hippocampal subregions supports memory function remains elusive. We studied the interregional coordination of CA3 neuronal spiking with CA1 theta oscillations by recording electrophysiological signals along the proximodistal axis of the hippocampus in rats that were performing a high-memory-demand recognition memory task adapted from humans. We found that CA3 population spiking occurs preferentially at the peak of distal CA1 theta oscillations when memory was tested but only when previously encountered stimuli were presented. In addition, decoding analyses revealed that only population cell firing of proximal CA3 together with that of distal CA1 can predict performance at test in the present non-spatial task. Overall, our work demonstrates an important role for the synchronization of CA3 neuronal activity with CA1 theta oscillations during memory testing."}],"status":"public","day":"25","quality_controlled":"1","has_accepted_license":"1","article_type":"original","volume":43,"file_date_updated":"2024-06-03T07:12:45Z","language":[{"iso":"eng"}],"author":[{"last_name":"Ku","first_name":"Shih Pi","full_name":"Ku, Shih Pi"},{"full_name":"Atucha, Erika","first_name":"Erika","last_name":"Atucha"},{"last_name":"Alavi","full_name":"Alavi, Nico","first_name":"Nico"},{"full_name":"Mulla-Osman, Halla","first_name":"Halla","last_name":"Mulla-Osman"},{"last_name":"Kayumova","first_name":"Rukhshona","full_name":"Kayumova, Rukhshona"},{"last_name":"Yoshida","full_name":"Yoshida, Motoharu","first_name":"Motoharu"},{"full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","first_name":"Jozsef L","last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Sauvage","full_name":"Sauvage, Magdalena M.","first_name":"Magdalena M."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JoCs"}],"publication":"Cell Reports","article_number":"114276","date_created":"2024-06-02T22:00:56Z","file":[{"content_type":"application/pdf","date_updated":"2024-06-03T07:12:45Z","file_name":"2024_CellReports_Ku.pdf","date_created":"2024-06-03T07:12:45Z","file_size":4371015,"relation":"main_file","success":1,"access_level":"open_access","file_id":"17096","checksum":"9b43f8ca5e5a12ae96e3fb9df06385c1","creator":"dernst"}],"year":"2024","ddc":["570"],"article_processing_charge":"Yes (in subscription journal)","date_published":"2024-06-25T00:00:00Z","_id":"17089","doi":"10.1016/j.celrep.2024.114276","publication_identifier":{"eissn":["2211-1247"]},"issue":"6","month":"06","title":"Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance","oa_version":"Published Version","type":"journal_article","citation":{"short":"S.P. Ku, E. Atucha, N. Alavi, H. Mulla-Osman, R. Kayumova, M. Yoshida, J.L. Csicsvari, M.M. Sauvage, Cell Reports 43 (2024).","apa":"Ku, S. P., Atucha, E., Alavi, N., Mulla-Osman, H., Kayumova, R., Yoshida, M., … Sauvage, M. M. (2024). Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2024.114276\">https://doi.org/10.1016/j.celrep.2024.114276</a>","ama":"Ku SP, Atucha E, Alavi N, et al. Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. <i>Cell Reports</i>. 2024;43(6). doi:<a href=\"https://doi.org/10.1016/j.celrep.2024.114276\">10.1016/j.celrep.2024.114276</a>","ista":"Ku SP, Atucha E, Alavi N, Mulla-Osman H, Kayumova R, Yoshida M, Csicsvari JL, Sauvage MM. 2024. Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. Cell Reports. 43(6), 114276.","ieee":"S. P. Ku <i>et al.</i>, “Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance,” <i>Cell Reports</i>, vol. 43, no. 6. Elsevier, 2024.","chicago":"Ku, Shih Pi, Erika Atucha, Nico Alavi, Halla Mulla-Osman, Rukhshona Kayumova, Motoharu Yoshida, Jozsef L Csicsvari, and Magdalena M. Sauvage. “Phase Locking of Hippocampal CA3 Neurons to Distal CA1 Theta Oscillations Selectively Predicts Memory Performance.” <i>Cell Reports</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.celrep.2024.114276\">https://doi.org/10.1016/j.celrep.2024.114276</a>.","mla":"Ku, Shih Pi, et al. “Phase Locking of Hippocampal CA3 Neurons to Distal CA1 Theta Oscillations Selectively Predicts Memory Performance.” <i>Cell Reports</i>, vol. 43, no. 6, 114276, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.celrep.2024.114276\">10.1016/j.celrep.2024.114276</a>."},"publisher":"Elsevier","scopus_import":"1","oa":1,"publication_status":"published"}