article published yes Shih Pi Ku author Erika Atucha author Nico Alavi author Halla Mulla-Osman author Rukhshona Kayumova author Motoharu Yoshida author Jozsef L Csicsvari author 3FA14672-F248-11E8-B48F-1D18A9856A870000-0002-5193-4036 Magdalena M. Sauvage author JoCs department How the coordination of neuronal spiking and brain rhythms between hippocampal subregions supports memory function remains elusive. We studied the interregional coordination of CA3 neuronal spiking with CA1 theta oscillations by recording electrophysiological signals along the proximodistal axis of the hippocampus in rats that were performing a high-memory-demand recognition memory task adapted from humans. We found that CA3 population spiking occurs preferentially at the peak of distal CA1 theta oscillations when memory was tested but only when previously encountered stimuli were presented. In addition, decoding analyses revealed that only population cell firing of proximal CA3 together with that of distal CA1 can predict performance at test in the present non-spatial task. Overall, our work demonstrates an important role for the synchronization of CA3 neuronal activity with CA1 theta oscillations during memory testing. https://research-explorer.ista.ac.at/download/17089/17096/2024_CellReports_Ku.pdf application/pdfno https://creativecommons.org/licenses/by/4.0/ Elsevier2024 eng 2211-1247 00125279260000110.1016/j.celrep.2024.114276 436 Ku SP, Atucha E, Alavi N, et al. Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. <i>Cell Reports</i>. 2024;43(6). doi:<a href="https://doi.org/10.1016/j.celrep.2024.114276">10.1016/j.celrep.2024.114276</a> S.P. Ku, E. Atucha, N. Alavi, H. Mulla-Osman, R. Kayumova, M. Yoshida, J.L. Csicsvari, M.M. Sauvage, Cell Reports 43 (2024). S. P. Ku <i>et al.</i>, “Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance,” <i>Cell Reports</i>, vol. 43, no. 6. Elsevier, 2024. Ku, S. P., Atucha, E., Alavi, N., Mulla-Osman, H., Kayumova, R., Yoshida, M., … Sauvage, M. M. (2024). Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. <i>Cell Reports</i>. Elsevier. <a href="https://doi.org/10.1016/j.celrep.2024.114276">https://doi.org/10.1016/j.celrep.2024.114276</a> Ku, Shih Pi, et al. “Phase Locking of Hippocampal CA3 Neurons to Distal CA1 Theta Oscillations Selectively Predicts Memory Performance.” <i>Cell Reports</i>, vol. 43, no. 6, 114276, Elsevier, 2024, doi:<a href="https://doi.org/10.1016/j.celrep.2024.114276">10.1016/j.celrep.2024.114276</a>. Ku SP, Atucha E, Alavi N, Mulla-Osman H, Kayumova R, Yoshida M, Csicsvari JL, Sauvage MM. 2024. Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. Cell Reports. 43(6), 114276. Ku, Shih Pi, Erika Atucha, Nico Alavi, Halla Mulla-Osman, Rukhshona Kayumova, Motoharu Yoshida, Jozsef L Csicsvari, and Magdalena M. Sauvage. “Phase Locking of Hippocampal CA3 Neurons to Distal CA1 Theta Oscillations Selectively Predicts Memory Performance.” <i>Cell Reports</i>. Elsevier, 2024. <a href="https://doi.org/10.1016/j.celrep.2024.114276">https://doi.org/10.1016/j.celrep.2024.114276</a>. 170892024-06-02T22:00:56Z2025-09-08T07:42:25Z