---
_id: '17089'
abstract:
- lang: eng
  text: How the coordination of neuronal spiking and brain rhythms between hippocampal
    subregions supports memory function remains elusive. We studied the interregional
    coordination of CA3 neuronal spiking with CA1 theta oscillations by recording
    electrophysiological signals along the proximodistal axis of the hippocampus in
    rats that were performing a high-memory-demand recognition memory task adapted
    from humans. We found that CA3 population spiking occurs preferentially at the
    peak of distal CA1 theta oscillations when memory was tested but only when previously
    encountered stimuli were presented. In addition, decoding analyses revealed that
    only population cell firing of proximal CA3 together with that of distal CA1 can
    predict performance at test in the present non-spatial task. Overall, our work
    demonstrates an important role for the synchronization of CA3 neuronal activity
    with CA1 theta oscillations during memory testing.
acknowledgement: We would like to thank J. Maiwald for her assistance in animal behavior
  training, experiments, and brain slice preparation; D. Koch for her assistance in
  recording drive building and brain slicing; K. Kaefer and J. Wallenschus (IST Austria)
  for their initial technical support; S. Mikulovich for her comments on an early
  version of the manuscript; C. Reichert for his comments on SVM analyses; and J.
  Pakan for English proofreading. This project is funded by the DFG (CRC 779 and CRC
  1436).
article_number: '114276'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Shih Pi
  full_name: Ku, Shih Pi
  last_name: Ku
- first_name: Erika
  full_name: Atucha, Erika
  last_name: Atucha
- first_name: Nico
  full_name: Alavi, Nico
  last_name: Alavi
- first_name: Halla
  full_name: Mulla-Osman, Halla
  last_name: Mulla-Osman
- first_name: Rukhshona
  full_name: Kayumova, Rukhshona
  last_name: Kayumova
- first_name: Motoharu
  full_name: Yoshida, Motoharu
  last_name: Yoshida
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
- first_name: Magdalena M.
  full_name: Sauvage, Magdalena M.
  last_name: Sauvage
citation:
  ama: Ku SP, Atucha E, Alavi N, et al. Phase locking of hippocampal CA3 neurons to
    distal CA1 theta oscillations selectively predicts memory performance. <i>Cell
    Reports</i>. 2024;43(6). doi:<a href="https://doi.org/10.1016/j.celrep.2024.114276">10.1016/j.celrep.2024.114276</a>
  apa: Ku, S. P., Atucha, E., Alavi, N., Mulla-Osman, H., Kayumova, R., Yoshida, M.,
    … Sauvage, M. M. (2024). Phase locking of hippocampal CA3 neurons to distal CA1
    theta oscillations selectively predicts memory performance. <i>Cell Reports</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.celrep.2024.114276">https://doi.org/10.1016/j.celrep.2024.114276</a>
  chicago: Ku, Shih Pi, Erika Atucha, Nico Alavi, Halla Mulla-Osman, Rukhshona Kayumova,
    Motoharu Yoshida, Jozsef L Csicsvari, and Magdalena M. Sauvage. “Phase Locking
    of Hippocampal CA3 Neurons to Distal CA1 Theta Oscillations Selectively Predicts
    Memory Performance.” <i>Cell Reports</i>. Elsevier, 2024. <a href="https://doi.org/10.1016/j.celrep.2024.114276">https://doi.org/10.1016/j.celrep.2024.114276</a>.
  ieee: S. P. Ku <i>et al.</i>, “Phase locking of hippocampal CA3 neurons to distal
    CA1 theta oscillations selectively predicts memory performance,” <i>Cell Reports</i>,
    vol. 43, no. 6. Elsevier, 2024.
  ista: Ku SP, Atucha E, Alavi N, Mulla-Osman H, Kayumova R, Yoshida M, Csicsvari
    JL, Sauvage MM. 2024. Phase locking of hippocampal CA3 neurons to distal CA1 theta
    oscillations selectively predicts memory performance. Cell Reports. 43(6), 114276.
  mla: Ku, Shih Pi, et al. “Phase Locking of Hippocampal CA3 Neurons to Distal CA1
    Theta Oscillations Selectively Predicts Memory Performance.” <i>Cell Reports</i>,
    vol. 43, no. 6, 114276, Elsevier, 2024, doi:<a href="https://doi.org/10.1016/j.celrep.2024.114276">10.1016/j.celrep.2024.114276</a>.
  short: S.P. Ku, E. Atucha, N. Alavi, H. Mulla-Osman, R. Kayumova, M. Yoshida, J.L.
    Csicsvari, M.M. Sauvage, Cell Reports 43 (2024).
date_created: 2024-06-02T22:00:56Z
date_published: 2024-06-25T00:00:00Z
date_updated: 2025-09-08T07:42:25Z
day: '25'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.celrep.2024.114276
external_id:
  isi:
  - '001252792600001'
file:
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  creator: dernst
  date_created: 2024-06-03T07:12:45Z
  date_updated: 2024-06-03T07:12:45Z
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file_date_updated: 2024-06-03T07:12:45Z
has_accepted_license: '1'
intvolume: '        43'
isi: 1
issue: '6'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '06'
oa: 1
oa_version: Published Version
publication: Cell Reports
publication_identifier:
  eissn:
  - 2211-1247
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively
  predicts memory performance
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 43
year: '2024'
...