{"external_id":{"pmid":["38561228"]},"language":[{"iso":"eng"}],"scopus_import":"1","ddc":["570"],"date_created":"2024-06-02T22:00:57Z","status":"public","day":"22","_id":"17092","publication":"Journal of Neuroscience","publication_status":"published","has_accepted_license":"1","date_published":"2024-05-22T00:00:00Z","article_processing_charge":"Yes (in subscription journal)","month":"05","publication_identifier":{"issn":["0270-6474"],"eissn":["1529-2401"]},"article_number":"e0846232024","oa_version":"Published Version","license":"https://creativecommons.org/licenses/by/4.0/","publisher":"Society of Neuroscience","author":[{"first_name":"Geoffroy","full_name":"Delamare, Geoffroy","last_name":"Delamare"},{"last_name":"Feitosa Tomé","id":"0eed2d40-3d48-11ec-8d38-f789cc2e40b2","full_name":"Feitosa Tomé, Douglas","first_name":"Douglas"},{"last_name":"Clopath","full_name":"Clopath, Claudia","first_name":"Claudia"}],"file":[{"file_name":"2024_JourNeuroscience_Delamare.pdf","relation":"main_file","date_updated":"2024-06-03T06:34:21Z","file_size":920354,"file_id":"17095","content_type":"application/pdf","date_created":"2024-06-03T06:34:21Z","success":1,"creator":"dernst","checksum":"4e19159800db605b802c721e4d4b1ffe","access_level":"open_access"}],"doi":"10.1523/JNEUROSCI.0846-23.2024","citation":{"ista":"Delamare G, Feitosa Tomé D, Clopath C. 2024. Intrinsic neural excitability biases allocation and overlap of memory engrams. Journal of Neuroscience. 44(21), e0846232024.","short":"G. Delamare, D. Feitosa Tomé, C. Clopath, Journal of Neuroscience 44 (2024).","chicago":"Delamare, Geoffroy, Douglas Feitosa Tomé, and Claudia Clopath. “Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.” <i>Journal of Neuroscience</i>. Society of Neuroscience, 2024. <a href=\"https://doi.org/10.1523/JNEUROSCI.0846-23.2024\">https://doi.org/10.1523/JNEUROSCI.0846-23.2024</a>.","mla":"Delamare, Geoffroy, et al. “Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.” <i>Journal of Neuroscience</i>, vol. 44, no. 21, e0846232024, Society of Neuroscience, 2024, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.0846-23.2024\">10.1523/JNEUROSCI.0846-23.2024</a>.","apa":"Delamare, G., Feitosa Tomé, D., &#38; Clopath, C. (2024). Intrinsic neural excitability biases allocation and overlap of memory engrams. <i>Journal of Neuroscience</i>. Society of Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.0846-23.2024\">https://doi.org/10.1523/JNEUROSCI.0846-23.2024</a>","ama":"Delamare G, Feitosa Tomé D, Clopath C. Intrinsic neural excitability biases allocation and overlap of memory engrams. <i>Journal of Neuroscience</i>. 2024;44(21). doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.0846-23.2024\">10.1523/JNEUROSCI.0846-23.2024</a>","ieee":"G. Delamare, D. Feitosa Tomé, and C. Clopath, “Intrinsic neural excitability biases allocation and overlap of memory engrams,” <i>Journal of Neuroscience</i>, vol. 44, no. 21. Society of Neuroscience, 2024."},"article_type":"original","pmid":1,"intvolume":"        44","title":"Intrinsic neural excitability biases allocation and overlap of memory engrams","type":"journal_article","acknowledgement":"We thank Sadra Sadeh and Inês Completo Guerreiro for helpful comments on the manuscript, Yosif Zaki and Denise J. Cai for useful feedback and members of the Clopath lab for discussion and support. This work was supported by Biotechnology and Biological Sciences Research Council (BB/N013956/1 awarded to C.C.), Wellcome Trust (200790/Z/16/Z awarded to C.C.), the Simons Foundation (564408 awarded to C.C.), and Engineering and Physical Sciences Research Council (EP/R035806/1 awarded to C.C.).","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2024-06-03T06:37:36Z","oa":1,"volume":44,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"TiVo"}],"year":"2024","file_date_updated":"2024-06-03T06:34:21Z","issue":"21","abstract":[{"lang":"eng","text":"Memories are thought to be stored in neural ensembles known as engrams that are specifically reactivated during memory recall. Recent studies have found that memory engrams of two events that happened close in time tend to overlap in the hippocampus and the amygdala, and these overlaps have been shown to support memory linking. It has been hypothesized that engram overlaps arise from the mechanisms that regulate memory allocation itself, involving neural excitability, but the exact process remains unclear. Indeed, most theoretical studies focus on synaptic plasticity and little is known about the role of intrinsic plasticity, which could be mediated by neural excitability and serve as a complementary mechanism for forming memory engrams. Here, we developed a rate-based recurrent neural network that includes both synaptic plasticity and neural excitability. We obtained structural and functional overlap of memory engrams for contexts that are presented close in time, consistent with experimental and computational studies. We then investigated the role of excitability in memory allocation at the network level and unveiled competitive mechanisms driven by inhibition. This work suggests mechanisms underlying the role of intrinsic excitability in memory allocation and linking, and yields predictions regarding the formation and the overlap of memory engrams."}],"quality_controlled":"1"}