---
_id: '17092'
abstract:
- lang: eng
  text: Memories are thought to be stored in neural ensembles known as engrams that
    are specifically reactivated during memory recall. Recent studies have found that
    memory engrams of two events that happened close in time tend to overlap in the
    hippocampus and the amygdala, and these overlaps have been shown to support memory
    linking. It has been hypothesized that engram overlaps arise from the mechanisms
    that regulate memory allocation itself, involving neural excitability, but the
    exact process remains unclear. Indeed, most theoretical studies focus on synaptic
    plasticity and little is known about the role of intrinsic plasticity, which could
    be mediated by neural excitability and serve as a complementary mechanism for
    forming memory engrams. Here, we developed a rate-based recurrent neural network
    that includes both synaptic plasticity and neural excitability. We obtained structural
    and functional overlap of memory engrams for contexts that are presented close
    in time, consistent with experimental and computational studies. We then investigated
    the role of excitability in memory allocation at the network level and unveiled
    competitive mechanisms driven by inhibition. This work suggests mechanisms underlying
    the role of intrinsic excitability in memory allocation and linking, and yields
    predictions regarding the formation and the overlap of memory engrams.
acknowledgement: We thank Sadra Sadeh and Inês Completo Guerreiro for helpful comments
  on the manuscript, Yosif Zaki and Denise J. Cai for useful feedback and members
  of the Clopath lab for discussion and support. This work was supported by Biotechnology
  and Biological Sciences Research Council (BB/N013956/1 awarded to C.C.), Wellcome
  Trust (200790/Z/16/Z awarded to C.C.), the Simons Foundation (564408 awarded to
  C.C.), and Engineering and Physical Sciences Research Council (EP/R035806/1 awarded
  to C.C.).
article_number: e0846232024
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Geoffroy
  full_name: Delamare, Geoffroy
  last_name: Delamare
- first_name: Douglas
  full_name: Feitosa Tomé, Douglas
  id: 0eed2d40-3d48-11ec-8d38-f789cc2e40b2
  last_name: Feitosa Tomé
- first_name: Claudia
  full_name: Clopath, Claudia
  last_name: Clopath
citation:
  ama: Delamare G, Feitosa Tomé D, Clopath C. Intrinsic neural excitability biases
    allocation and overlap of memory engrams. <i>Journal of Neuroscience</i>. 2024;44(21).
    doi:<a href="https://doi.org/10.1523/JNEUROSCI.0846-23.2024">10.1523/JNEUROSCI.0846-23.2024</a>
  apa: Delamare, G., Feitosa Tomé, D., &#38; Clopath, C. (2024). Intrinsic neural
    excitability biases allocation and overlap of memory engrams. <i>Journal of Neuroscience</i>.
    Society for Neuroscience. <a href="https://doi.org/10.1523/JNEUROSCI.0846-23.2024">https://doi.org/10.1523/JNEUROSCI.0846-23.2024</a>
  chicago: Delamare, Geoffroy, Douglas Feitosa Tomé, and Claudia Clopath. “Intrinsic
    Neural Excitability Biases Allocation and Overlap of Memory Engrams.” <i>Journal
    of Neuroscience</i>. Society for Neuroscience, 2024. <a href="https://doi.org/10.1523/JNEUROSCI.0846-23.2024">https://doi.org/10.1523/JNEUROSCI.0846-23.2024</a>.
  ieee: G. Delamare, D. Feitosa Tomé, and C. Clopath, “Intrinsic neural excitability
    biases allocation and overlap of memory engrams,” <i>Journal of Neuroscience</i>,
    vol. 44, no. 21. Society for Neuroscience, 2024.
  ista: Delamare G, Feitosa Tomé D, Clopath C. 2024. Intrinsic neural excitability
    biases allocation and overlap of memory engrams. Journal of Neuroscience. 44(21),
    e0846232024.
  mla: Delamare, Geoffroy, et al. “Intrinsic Neural Excitability Biases Allocation
    and Overlap of Memory Engrams.” <i>Journal of Neuroscience</i>, vol. 44, no. 21,
    e0846232024, Society for Neuroscience, 2024, doi:<a href="https://doi.org/10.1523/JNEUROSCI.0846-23.2024">10.1523/JNEUROSCI.0846-23.2024</a>.
  short: G. Delamare, D. Feitosa Tomé, C. Clopath, Journal of Neuroscience 44 (2024).
date_created: 2024-06-02T22:00:57Z
date_published: 2024-05-22T00:00:00Z
date_updated: 2025-09-08T07:40:58Z
day: '22'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1523/JNEUROSCI.0846-23.2024
external_id:
  isi:
  - '001249681000008'
  pmid:
  - '38561228'
file:
- access_level: open_access
  checksum: 4e19159800db605b802c721e4d4b1ffe
  content_type: application/pdf
  creator: dernst
  date_created: 2024-06-03T06:34:21Z
  date_updated: 2024-06-03T06:34:21Z
  file_id: '17095'
  file_name: 2024_JourNeuroscience_Delamare.pdf
  file_size: 920354
  relation: main_file
  success: 1
file_date_updated: 2024-06-03T06:34:21Z
has_accepted_license: '1'
intvolume: '        44'
isi: 1
issue: '21'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
  eissn:
  - 1529-2401
  issn:
  - 0270-6474
publication_status: published
publisher: Society for Neuroscience
quality_controlled: '1'
scopus_import: '1'
status: public
title: Intrinsic neural excitability biases allocation and overlap of memory engrams
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 44
year: '2024'
...