---
res:
  bibo_abstract:
  - 'The homeostasis of epithelial tissue relies on a balance between the self-renewal
    of stem cell populations, cellular differentiation, and loss. Although this balance
    needs to be tightly regulated to avoid pathologies, such as tumor growth, the
    regulatory mechanisms, both cell-intrinsic and collective, which ensure tissue
    steady-state are still poorly understood. Here, we develop a computational model
    that incorporates basic assumptions of stem cell renewal into distinct populations
    and mechanical interactions between cells. We find that the model generates unexpected
    dynamic features: stem cells repel each other in the bulk tissue and are thus
    found rather isolated, as in a number of in vivo contexts. By mapping the system
    onto a gas of passive Brownian particles with effective repulsive interactions,
    that arise from the generated flows of differentiated cells, we show that we can
    quantitatively describe such stem cell distribution in tissues. The interaction
    potential between a pair of stem cells decays exponentially with a characteristic
    length that spans several cell sizes, corresponding to the volume of cells generated
    per stem cell division. Our findings may help understanding the dynamics of normal
    and cancerous epithelial tissues.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Johannes C.
      foaf_name: Krämer, Johannes C.
      foaf_surname: Krämer
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Gerhard
      foaf_name: Gompper, Gerhard
      foaf_surname: Gompper
  - foaf_Person:
      foaf_givenName: Jens
      foaf_name: Elgeti, Jens
      foaf_surname: Elgeti
  bibo_doi: 10.21468/scipostphys.16.4.097
  bibo_issue: '4'
  bibo_volume: 16
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001202370200001
  dct_isPartOf:
  - http://id.crossref.org/issn/2542-4653
  dct_language: eng
  dct_publisher: SciPost Foundation@
  dct_title: Mechanically-driven stem cell separation in tissues caused by proliferating
    daughter cells@
...