---
_id: '17104'
abstract:
- lang: eng
  text: 'The homeostasis of epithelial tissue relies on a balance between the self-renewal
    of stem cell populations, cellular differentiation, and loss. Although this balance
    needs to be tightly regulated to avoid pathologies, such as tumor growth, the
    regulatory mechanisms, both cell-intrinsic and collective, which ensure tissue
    steady-state are still poorly understood. Here, we develop a computational model
    that incorporates basic assumptions of stem cell renewal into distinct populations
    and mechanical interactions between cells. We find that the model generates unexpected
    dynamic features: stem cells repel each other in the bulk tissue and are thus
    found rather isolated, as in a number of in vivo contexts. By mapping the system
    onto a gas of passive Brownian particles with effective repulsive interactions,
    that arise from the generated flows of differentiated cells, we show that we can
    quantitatively describe such stem cell distribution in tissues. The interaction
    potential between a pair of stem cells decays exponentially with a characteristic
    length that spans several cell sizes, corresponding to the volume of cells generated
    per stem cell division. Our findings may help understanding the dynamics of normal
    and cancerous epithelial tissues.'
acknowledgement: JE and JK gratefully acknowledge financial support from the Initiative
  and Networking Fund (IVF) via the grant number ERC-RA-004. Simulations were performed
  with computing resources granted by RWTH Aachen University under project ‘rwth0475’.
article_number: '097'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Johannes C.
  full_name: Krämer, Johannes C.
  last_name: Krämer
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Gerhard
  full_name: Gompper, Gerhard
  last_name: Gompper
- first_name: Jens
  full_name: Elgeti, Jens
  last_name: Elgeti
citation:
  ama: Krämer JC, Hannezo EB, Gompper G, Elgeti J. Mechanically-driven stem cell separation
    in tissues caused by proliferating daughter cells. <i>SciPost Physics</i>. 2024;16(4).
    doi:<a href="https://doi.org/10.21468/scipostphys.16.4.097">10.21468/scipostphys.16.4.097</a>
  apa: Krämer, J. C., Hannezo, E. B., Gompper, G., &#38; Elgeti, J. (2024). Mechanically-driven
    stem cell separation in tissues caused by proliferating daughter cells. <i>SciPost
    Physics</i>. SciPost Foundation. <a href="https://doi.org/10.21468/scipostphys.16.4.097">https://doi.org/10.21468/scipostphys.16.4.097</a>
  chicago: Krämer, Johannes C., Edouard B Hannezo, Gerhard Gompper, and Jens Elgeti.
    “Mechanically-Driven Stem Cell Separation in Tissues Caused by Proliferating Daughter
    Cells.” <i>SciPost Physics</i>. SciPost Foundation, 2024. <a href="https://doi.org/10.21468/scipostphys.16.4.097">https://doi.org/10.21468/scipostphys.16.4.097</a>.
  ieee: J. C. Krämer, E. B. Hannezo, G. Gompper, and J. Elgeti, “Mechanically-driven
    stem cell separation in tissues caused by proliferating daughter cells,” <i>SciPost
    Physics</i>, vol. 16, no. 4. SciPost Foundation, 2024.
  ista: Krämer JC, Hannezo EB, Gompper G, Elgeti J. 2024. Mechanically-driven stem
    cell separation in tissues caused by proliferating daughter cells. SciPost Physics.
    16(4), 097.
  mla: Krämer, Johannes C., et al. “Mechanically-Driven Stem Cell Separation in Tissues
    Caused by Proliferating Daughter Cells.” <i>SciPost Physics</i>, vol. 16, no.
    4, 097, SciPost Foundation, 2024, doi:<a href="https://doi.org/10.21468/scipostphys.16.4.097">10.21468/scipostphys.16.4.097</a>.
  short: J.C. Krämer, E.B. Hannezo, G. Gompper, J. Elgeti, SciPost Physics 16 (2024).
date_created: 2024-06-03T08:58:44Z
date_published: 2024-04-08T00:00:00Z
date_updated: 2025-09-08T07:45:40Z
day: '08'
ddc:
- '530'
department:
- _id: EdHa
doi: 10.21468/scipostphys.16.4.097
external_id:
  arxiv:
  - '2310.04272'
  isi:
  - '001202370200001'
file:
- access_level: open_access
  checksum: 6fdeecd21c166db8dedb927ecc2e6025
  content_type: application/pdf
  creator: dernst
  date_created: 2024-06-03T11:18:51Z
  date_updated: 2024-06-03T11:18:51Z
  file_id: '17109'
  file_name: 2024_SciPostPhys_Kraemer.pdf
  file_size: 4973291
  relation: main_file
  success: 1
file_date_updated: 2024-06-03T11:18:51Z
has_accepted_license: '1'
intvolume: '        16'
isi: 1
issue: '4'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '04'
oa: 1
oa_version: Published Version
publication: SciPost Physics
publication_identifier:
  issn:
  - 2542-4653
publication_status: published
publisher: SciPost Foundation
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanically-driven stem cell separation in tissues caused by proliferating
  daughter cells
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 16
year: '2024'
...