{"file":[{"relation":"main_file","file_size":1023680,"date_created":"2018-12-12T10:14:44Z","checksum":"bbb1ee39ca52929aefe4f48752b166ee","access_level":"open_access","creator":"system","file_id":"5098","file_name":"IST-2015-346-v1+1_Current_Opinion_Review_Ratheesh_et_al_2015.pdf","date_updated":"2020-07-14T12:45:13Z","content_type":"application/pdf"}],"publisher":"Elsevier","day":"01","department":[{"_id":"DaSi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"The majority of immune cells in Drosophila melanogaster are plasmatocytes; they carry out similar functions to vertebrate macrophages, influencing development as well as protecting against infection and cancer. Plasmatocytes, sometimes referred to with the broader term of hemocytes, migrate widely during embryonic development and cycle in the larvae between sessile and circulating positions. Here we discuss the similarities of plasmatocyte developmental migration and its functions to that of vertebrate macrophages, considering the recent controversy regarding the functions of Drosophila PDGF/VEGF related ligands. We also examine recent findings on the significance of adhesion for plasmatocyte migration in the embryo, as well as proliferation, trans-differentiation, and tumor responses in the larva. We spotlight parallels throughout to vertebrate immune responses.","lang":"eng"}],"volume":36,"file_date_updated":"2020-07-14T12:45:13Z","date_created":"2018-12-11T11:53:36Z","publication_status":"published","publication":"Current Opinion in Cell Biology","language":[{"iso":"eng"}],"_id":"1712","oa":1,"scopus_import":1,"tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"intvolume":"        36","date_published":"2015-10-01T00:00:00Z","citation":{"apa":"Ratheesh, A., Belyaeva, V., &#38; Siekhaus, D. E. (2015). Drosophila immune cell migration and adhesion during embryonic development and larval immune responses. <i>Current Opinion in Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ceb.2015.07.003\">https://doi.org/10.1016/j.ceb.2015.07.003</a>","ista":"Ratheesh A, Belyaeva V, Siekhaus DE. 2015. Drosophila immune cell migration and adhesion during embryonic development and larval immune responses. Current Opinion in Cell Biology. 36(10), 71–79.","chicago":"Ratheesh, Aparna, Vera Belyaeva, and Daria E Siekhaus. “Drosophila Immune Cell Migration and Adhesion during Embryonic Development and Larval Immune Responses.” <i>Current Opinion in Cell Biology</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.ceb.2015.07.003\">https://doi.org/10.1016/j.ceb.2015.07.003</a>.","ieee":"A. Ratheesh, V. Belyaeva, and D. E. Siekhaus, “Drosophila immune cell migration and adhesion during embryonic development and larval immune responses,” <i>Current Opinion in Cell Biology</i>, vol. 36, no. 10. Elsevier, pp. 71–79, 2015.","ama":"Ratheesh A, Belyaeva V, Siekhaus DE. Drosophila immune cell migration and adhesion during embryonic development and larval immune responses. <i>Current Opinion in Cell Biology</i>. 2015;36(10):71-79. doi:<a href=\"https://doi.org/10.1016/j.ceb.2015.07.003\">10.1016/j.ceb.2015.07.003</a>","mla":"Ratheesh, Aparna, et al. “Drosophila Immune Cell Migration and Adhesion during Embryonic Development and Larval Immune Responses.” <i>Current Opinion in Cell Biology</i>, vol. 36, no. 10, Elsevier, 2015, pp. 71–79, doi:<a href=\"https://doi.org/10.1016/j.ceb.2015.07.003\">10.1016/j.ceb.2015.07.003</a>.","short":"A. Ratheesh, V. Belyaeva, D.E. Siekhaus, Current Opinion in Cell Biology 36 (2015) 71–79."},"title":"Drosophila immune cell migration and adhesion during embryonic development and larval immune responses","quality_controlled":"1","project":[{"name":"Investigating the role of transporters in invasive migration through junctions","call_identifier":"FP7","_id":"2536F660-B435-11E9-9278-68D0E5697425","grant_number":"334077"}],"pubrep_id":"346","ec_funded":1,"month":"10","year":"2015","oa_version":"Published Version","date_updated":"2021-01-12T06:52:41Z","publist_id":"5421","status":"public","author":[{"first_name":"Aparna","last_name":"Ratheesh","full_name":"Ratheesh, Aparna","id":"2F064CFE-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Belyaeva, Vera","id":"47F080FE-F248-11E8-B48F-1D18A9856A87","first_name":"Vera","last_name":"Belyaeva"},{"orcid":"0000-0001-8323-8353","first_name":"Daria E","last_name":"Siekhaus","full_name":"Siekhaus, Daria E","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87"}],"issue":"10","ddc":["573"],"has_accepted_license":"1","page":"71 - 79","type":"journal_article","doi":"10.1016/j.ceb.2015.07.003"}