---
res:
  bibo_abstract:
  - A key feature of many developmental systems is their ability to self-organize
    spatial patterns of functionally distinct cell fates. To ensure proper biological
    function, such patterns must be established reproducibly, by controlling and even
    harnessing intrinsic and extrinsic fluctuations. While the relevant molecular
    processes are increasingly well understood, we lack a principled framework to
    quantify the performance of such stochastic self-organizing systems. To that end,
    we introduce an information-theoretic measure for self-organized fate specification
    during embryonic development. We show that the proposed measure assesses the total
    information content of fate patterns and decomposes it into interpretable contributions
    corresponding to the positional and correlational information. By optimizing the
    proposed measure, our framework provides a normative theory for developmental
    circuits, which we demonstrate on lateral inhibition, cell type proportioning,
    and reaction–diffusion models of self-organization. This paves a way toward a
    classification of developmental systems based on a common information-theoretic
    language, thereby organizing the zoo of implicated chemical and mechanical signaling
    processes.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Brückner, David
      foaf_surname: Brückner
      foaf_workInfoHomepage: http://www.librecat.org/personId=e1e86031-6537-11eb-953a-f7ab92be508d
    orcid: 0000-0001-7205-2975
  - foaf_Person:
      foaf_givenName: Gašper
      foaf_name: Tkačik, Gašper
      foaf_surname: Tkačik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  bibo_doi: 10.1073/pnas.2322326121
  bibo_issue: '23'
  bibo_volume: 121
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001244835000006
  dct_isPartOf:
  - http://id.crossref.org/issn/0027-8424
  - http://id.crossref.org/issn/1091-6490
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: Information content and optimization of self-organized developmental
    systems@
  fabio_hasPubmedId: '38819997'
...