---
res:
  bibo_abstract:
  - Efficient utilization of large-scale biobank data is crucial for inferring the
    genetic basis of disease and predicting health outcomes from the DNA. Yet we lack
    efficient, accurate methods that scale to data where electronic health records
    are linked to whole genome sequence information. To address this issue, our paper
    develops a new algorithmic paradigm based on Approximate Message Passing (AMP),
    which is specifically tailored for genomic prediction and association testing.
    Our method yields comparable out-of-sample prediction accuracy to the state of
    the art on UK Biobank traits, whilst dramatically improving computational complexity,
    with a 8x-speed up in the run time. In addition, AMP theory provides a joint association
    testing framework, which outperforms the currently used REGENIE method, in roughly
    a third of the compute time. This first, truly large-scale application of the
    AMP framework lays the foundations for a far wider range of statistical analyses
    for hundreds of millions of variables measured on millions of people.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Al
      foaf_name: Depope, Al
      foaf_surname: Depope
      foaf_workInfoHomepage: http://www.librecat.org/personId=0b77531d-dbcd-11ea-9d1d-a8eee0bf3830
  - foaf_Person:
      foaf_givenName: Marco
      foaf_name: Mondelli, Marco
      foaf_surname: Mondelli
      foaf_workInfoHomepage: http://www.librecat.org/personId=27EB676C-8706-11E9-9510-7717E6697425
    orcid: 0000-0002-3242-7020
  - foaf_Person:
      foaf_givenName: Matthew Richard
      foaf_name: Robinson, Matthew Richard
      foaf_surname: Robinson
      foaf_workInfoHomepage: http://www.librecat.org/personId=E5D42276-F5DA-11E9-8E24-6303E6697425
    orcid: 0000-0001-8982-8813
  bibo_doi: 10.1109/ICASSP48485.2024.10447198
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001396233806078
  dct_isPartOf:
  - http://id.crossref.org/issn/1520-6149
  - http://id.crossref.org/issn/9798350344851
  dct_language: eng
  dct_publisher: IEEE@
  dct_title: Inference of genetic effects via approximate message passing@
...