---
res:
  bibo_abstract:
  - During neural tube (NT) development, the notochord induces an organizer, the floorplate,
    which secretes Sonic Hedgehog (SHH) to pattern neural progenitors. Conversely,
    NT organoids (NTOs) from embryonic stem cells (ESCs) spontaneously form floorplates
    without the notochord, demonstrating that stem cells can self-organize without
    embryonic inducers. Here, we investigated floorplate self-organization in clonal
    mouse NTOs. Expression of the floorplate marker FOXA2 was initially spatially
    scattered before resolving into multiple clusters, which underwent competition
    and sorting, resulting in a stable “winning” floorplate. We identified that BMP
    signaling governed long-range cluster competition. FOXA2+ clusters expressed BMP4,
    suppressing FOXA2 in receiving cells while simultaneously expressing the BMP-inhibitor
    NOGGIN, promoting cluster persistence. Noggin mutation perturbed floorplate formation
    in NTOs and in the NT in vivo at mid/hindbrain regions, demonstrating how the
    floorplate can form autonomously without the notochord. Identifying the pathways
    governing organizer self-organization is critical for harnessing the developmental
    plasticity of stem cells in tissue engineering.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Teresa
      foaf_name: Krammer, Teresa
      foaf_surname: Krammer
  - foaf_Person:
      foaf_givenName: Hannah T.
      foaf_name: Stuart, Hannah T.
      foaf_surname: Stuart
  - foaf_Person:
      foaf_givenName: Elena
      foaf_name: Gromberg, Elena
      foaf_surname: Gromberg
  - foaf_Person:
      foaf_givenName: Keisuke
      foaf_name: Ishihara, Keisuke
      foaf_surname: Ishihara
  - foaf_Person:
      foaf_givenName: Dillon
      foaf_name: Cislo, Dillon
      foaf_surname: Cislo
  - foaf_Person:
      foaf_givenName: Manuela
      foaf_name: Melchionda, Manuela
      foaf_surname: Melchionda
  - foaf_Person:
      foaf_givenName: Fernando
      foaf_name: Becerril Perez, Fernando
      foaf_surname: Becerril Perez
  - foaf_Person:
      foaf_givenName: Jingkui
      foaf_name: Wang, Jingkui
      foaf_surname: Wang
  - foaf_Person:
      foaf_givenName: Elena
      foaf_name: Costantini, Elena
      foaf_surname: Costantini
  - foaf_Person:
      foaf_givenName: Stefanie
      foaf_name: Rus, Stefanie
      foaf_surname: Rus
      foaf_workInfoHomepage: http://www.librecat.org/personId=4D9EC9B6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8703-1093
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Arbanas, Laura
      foaf_surname: Arbanas
  - foaf_Person:
      foaf_givenName: Alexandra
      foaf_name: Hörmann, Alexandra
      foaf_surname: Hörmann
  - foaf_Person:
      foaf_givenName: Ralph A.
      foaf_name: Neumüller, Ralph A.
      foaf_surname: Neumüller
  - foaf_Person:
      foaf_givenName: Nicola
      foaf_name: Elvassore, Nicola
      foaf_surname: Elvassore
  - foaf_Person:
      foaf_givenName: Eric
      foaf_name: Siggia, Eric
      foaf_surname: Siggia
  - foaf_Person:
      foaf_givenName: James
      foaf_name: Briscoe, James
      foaf_surname: Briscoe
  - foaf_Person:
      foaf_givenName: Anna
      foaf_name: Kicheva, Anna
      foaf_surname: Kicheva
      foaf_workInfoHomepage: http://www.librecat.org/personId=3959A2A0-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4509-4998
  - foaf_Person:
      foaf_givenName: Elly M.
      foaf_name: Tanaka, Elly M.
      foaf_surname: Tanaka
  bibo_doi: 10.1016/j.devcel.2024.04.021
  bibo_issue: '15'
  bibo_volume: 59
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001289684800001
  dct_isPartOf:
  - http://id.crossref.org/issn/1534-5807
  - http://id.crossref.org/issn/1878-1551
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Mouse neural tube organoids self-organize floorplate through BMP-mediated
    cluster competition@
  fabio_hasPubmedId: '38776925'
...