--- _id: '1718' abstract: - lang: eng text: Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a signaling gradient regulates differential gene expression in a concentration-dependent manner, has received considerable experimental support. Nevertheless, several recent studies have challenged the straightforward model of morphogen activity. In particular, the observation that pattern formation is a dynamic process has raised questions about the influence of time on morphogen activity. Here we propose that the spatiotemporal dynamics of the cellular response to a morphogen gradient depend on a combination of temporal alterations to the morphogen gradient itself, the dynamics of its signal transduction and downstream interactions between target genes. acknowledgement: EK is supported by an EMBO LTF, AK by a FEBS fellowship, and JB by MRC (UK) and the Wellcome Trust author: - first_name: Eva full_name: Kutějová, Eva last_name: Kutějová - first_name: James full_name: Briscoe, James last_name: Briscoe - first_name: Anna full_name: Anna Kicheva id: 3959A2A0-F248-11E8-B48F-1D18A9856A87 last_name: Kicheva orcid: 0000-0003-4509-4998 citation: ama: Kutějová E, Briscoe J, Kicheva A. Temporal dynamics of patterning by morphogen gradients. Current Opinion in Genetics & Development. 2009;19(4):315-322. doi:10.1016/j.gde.2009.05.004 apa: Kutějová, E., Briscoe, J., & Kicheva, A. (2009). Temporal dynamics of patterning by morphogen gradients. Current Opinion in Genetics & Development. Elsevier. https://doi.org/10.1016/j.gde.2009.05.004 chicago: Kutějová, Eva, James Briscoe, and Anna Kicheva. “Temporal Dynamics of Patterning by Morphogen Gradients.” Current Opinion in Genetics & Development. Elsevier, 2009. https://doi.org/10.1016/j.gde.2009.05.004. ieee: E. Kutějová, J. Briscoe, and A. Kicheva, “Temporal dynamics of patterning by morphogen gradients,” Current Opinion in Genetics & Development, vol. 19, no. 4. Elsevier, pp. 315–322, 2009. ista: Kutějová E, Briscoe J, Kicheva A. 2009. Temporal dynamics of patterning by morphogen gradients. Current Opinion in Genetics & Development. 19(4), 315–322. mla: Kutějová, Eva, et al. “Temporal Dynamics of Patterning by Morphogen Gradients.” Current Opinion in Genetics & Development, vol. 19, no. 4, Elsevier, 2009, pp. 315–22, doi:10.1016/j.gde.2009.05.004. short: E. Kutějová, J. Briscoe, A. Kicheva, Current Opinion in Genetics & Development 19 (2009) 315–322. date_created: 2018-12-11T11:53:38Z date_published: 2009-08-01T00:00:00Z date_updated: 2021-01-12T06:52:44Z day: '01' doi: 10.1016/j.gde.2009.05.004 extern: 1 intvolume: ' 19' issue: '4' month: '08' page: 315 - 322 publication: Current Opinion in Genetics & Development publication_status: published publisher: Elsevier publist_id: '5410' quality_controlled: 0 status: public title: Temporal dynamics of patterning by morphogen gradients type: journal_article volume: 19 year: '2009' ...