---
_id: '1718'
abstract:
- lang: eng
text: Morphogens act as graded positional cues to control cell fate specification
in many developing tissues. This concept, in which a signaling gradient regulates
differential gene expression in a concentration-dependent manner, has received
considerable experimental support. Nevertheless, several recent studies have challenged
the straightforward model of morphogen activity. In particular, the observation
that pattern formation is a dynamic process has raised questions about the influence
of time on morphogen activity. Here we propose that the spatiotemporal dynamics
of the cellular response to a morphogen gradient depend on a combination of temporal
alterations to the morphogen gradient itself, the dynamics of its signal transduction
and downstream interactions between target genes.
acknowledgement: EK is supported by an EMBO LTF, AK by a FEBS fellowship, and JB by
MRC (UK) and the Wellcome Trust
author:
- first_name: Eva
full_name: Kutějová, Eva
last_name: Kutějová
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: Kutějová E, Briscoe J, Kicheva A. Temporal dynamics of patterning by morphogen
gradients. Current Opinion in Genetics & Development. 2009;19(4):315-322.
doi:10.1016/j.gde.2009.05.004
apa: Kutějová, E., Briscoe, J., & Kicheva, A. (2009). Temporal dynamics of patterning
by morphogen gradients. Current Opinion in Genetics & Development.
Elsevier. https://doi.org/10.1016/j.gde.2009.05.004
chicago: Kutějová, Eva, James Briscoe, and Anna Kicheva. “Temporal Dynamics of Patterning
by Morphogen Gradients.” Current Opinion in Genetics & Development.
Elsevier, 2009. https://doi.org/10.1016/j.gde.2009.05.004.
ieee: E. Kutějová, J. Briscoe, and A. Kicheva, “Temporal dynamics of patterning
by morphogen gradients,” Current Opinion in Genetics & Development,
vol. 19, no. 4. Elsevier, pp. 315–322, 2009.
ista: Kutějová E, Briscoe J, Kicheva A. 2009. Temporal dynamics of patterning by
morphogen gradients. Current Opinion in Genetics & Development. 19(4), 315–322.
mla: Kutějová, Eva, et al. “Temporal Dynamics of Patterning by Morphogen Gradients.”
Current Opinion in Genetics & Development, vol. 19, no. 4, Elsevier,
2009, pp. 315–22, doi:10.1016/j.gde.2009.05.004.
short: E. Kutějová, J. Briscoe, A. Kicheva, Current Opinion in Genetics & Development
19 (2009) 315–322.
date_created: 2018-12-11T11:53:38Z
date_published: 2009-08-01T00:00:00Z
date_updated: 2021-01-12T06:52:44Z
day: '01'
doi: 10.1016/j.gde.2009.05.004
extern: 1
intvolume: ' 19'
issue: '4'
month: '08'
page: 315 - 322
publication: Current Opinion in Genetics & Development
publication_status: published
publisher: Elsevier
publist_id: '5410'
quality_controlled: 0
status: public
title: Temporal dynamics of patterning by morphogen gradients
type: journal_article
volume: 19
year: '2009'
...