{"abstract":[{"text":"How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms of gradient formation is provided. We then discuss the advantages and limitations of different experimental approaches to gradient formation analysis.","lang":"eng"}],"publisher":"Cold Spring Harbor Laboratory Press","title":"Morphogen gradient formation ","type":"journal_article","year":"2009","status":"public","volume":1,"day":"01","citation":{"ama":"Wartlick O, Kicheva A, González Gaitán M. Morphogen gradient formation . <i>Cold Spring Harbor perspectives in biology</i>. 2009;1(3). doi:<a href=\"https://doi.org/10.1101/cshperspect.a001255\">10.1101/cshperspect.a001255</a>","apa":"Wartlick, O., Kicheva, A., &#38; González Gaitán, M. (2009). Morphogen gradient formation . <i>Cold Spring Harbor Perspectives in Biology</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/cshperspect.a001255\">https://doi.org/10.1101/cshperspect.a001255</a>","short":"O. Wartlick, A. Kicheva, M. González Gaitán, Cold Spring Harbor Perspectives in Biology 1 (2009).","ista":"Wartlick O, Kicheva A, González Gaitán M. 2009. Morphogen gradient formation . Cold Spring Harbor perspectives in biology. 1(3).","mla":"Wartlick, Ortrud, et al. “Morphogen Gradient Formation .” <i>Cold Spring Harbor Perspectives in Biology</i>, vol. 1, no. 3, Cold Spring Harbor Laboratory Press, 2009, doi:<a href=\"https://doi.org/10.1101/cshperspect.a001255\">10.1101/cshperspect.a001255</a>.","chicago":"Wartlick, Ortrud, Anna Kicheva, and Marcos González Gaitán. “Morphogen Gradient Formation .” <i>Cold Spring Harbor Perspectives in Biology</i>. Cold Spring Harbor Laboratory Press, 2009. <a href=\"https://doi.org/10.1101/cshperspect.a001255\">https://doi.org/10.1101/cshperspect.a001255</a>.","ieee":"O. Wartlick, A. Kicheva, and M. González Gaitán, “Morphogen gradient formation ,” <i>Cold Spring Harbor perspectives in biology</i>, vol. 1, no. 3. Cold Spring Harbor Laboratory Press, 2009."},"extern":1,"intvolume":"         1","date_updated":"2021-01-12T06:52:45Z","_id":"1720","publist_id":"5409","date_created":"2018-12-11T11:53:39Z","issue":"3","quality_controlled":0,"date_published":"2009-09-01T00:00:00Z","doi":"10.1101/cshperspect.a001255","month":"09","author":[{"last_name":"Wartlick","first_name":"Ortrud","full_name":"Wartlick, Ortrud"},{"full_name":"Anna Kicheva","first_name":"Anna","last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4509-4998"},{"full_name":"González-Gaitán, Marcos A","first_name":"Marcos","last_name":"González Gaitán"}],"publication":"Cold Spring Harbor perspectives in biology","publication_status":"published"}