---
res:
  bibo_abstract:
  - "Background: The remarkable regenerative abilities observed in planarians and
    cnidarians are closely linked to the active proliferation of adult stem cells
    and the precise differentiation of their progeny, both of which typically deteriorate
    during aging in low regenerative animals. While regeneration-specific genes conserved
    in highly regenerative organisms may confer regenerative abilities and long-term
    maintenance of tissue homeostasis, it remains unclear whether introducing these
    regenerative genes into low regenerative animals can improve their regeneration
    and aging processes.\r\n\r\nResults: Here, we ectopically express highly regenerative
    species-specific JmjC domain-encoding genes (HRJDs) in Drosophila, a widely used
    low regenerative model organism. Surprisingly, HRJD expression impedes tissue
    regeneration in the developing wing disc but extends organismal lifespan when
    expressed in the intestinal stem cell lineages of the adult midgut under non-regenerative
    conditions. Notably, HRJDs enhance the proliferative activity of intestinal stem
    cells while maintaining their differentiation fidelity, ameliorating age-related
    decline in gut barrier functions.\r\n\r\nConclusions: These findings together
    suggest that the introduction of highly regenerative species-specific genes can
    improve stem cell functions and promote a healthy lifespan when expressed in aging
    animals.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Hiroki
      foaf_name: Nagai, Hiroki
      foaf_surname: Nagai
      foaf_workInfoHomepage: http://www.librecat.org/personId=608df3e6-e2ab-11ed-8890-c9318cec7da4
    orcid: 0000-0003-1671-9434
  - foaf_Person:
      foaf_givenName: Yuya
      foaf_name: Adachi, Yuya
      foaf_surname: Adachi
  - foaf_Person:
      foaf_givenName: Tenki
      foaf_name: Nakasugi, Tenki
      foaf_surname: Nakasugi
  - foaf_Person:
      foaf_givenName: Ema
      foaf_name: Takigawa, Ema
      foaf_surname: Takigawa
  - foaf_Person:
      foaf_givenName: Junichiro
      foaf_name: Ui, Junichiro
      foaf_surname: Ui
  - foaf_Person:
      foaf_givenName: Takashi
      foaf_name: Makino, Takashi
      foaf_surname: Makino
  - foaf_Person:
      foaf_givenName: Masayuki
      foaf_name: Miura, Masayuki
      foaf_surname: Miura
  - foaf_Person:
      foaf_givenName: Yu Ichiro
      foaf_name: Nakajima, Yu Ichiro
      foaf_surname: Nakajima
  bibo_doi: 10.1186/s12915-024-01956-4
  bibo_volume: 22
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001282893200001
  dct_isPartOf:
  - http://id.crossref.org/issn/1741-7007
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Highly regenerative species-specific genes improve age-associated features
    in the adult Drosophila midgut@
  fabio_hasPubmedId: '39090637'
...