---
_id: '17408'
abstract:
- lang: eng
  text: "Background: The remarkable regenerative abilities observed in planarians
    and cnidarians are closely linked to the active proliferation of adult stem cells
    and the precise differentiation of their progeny, both of which typically deteriorate
    during aging in low regenerative animals. While regeneration-specific genes conserved
    in highly regenerative organisms may confer regenerative abilities and long-term
    maintenance of tissue homeostasis, it remains unclear whether introducing these
    regenerative genes into low regenerative animals can improve their regeneration
    and aging processes.\r\n\r\nResults: Here, we ectopically express highly regenerative
    species-specific JmjC domain-encoding genes (HRJDs) in Drosophila, a widely used
    low regenerative model organism. Surprisingly, HRJD expression impedes tissue
    regeneration in the developing wing disc but extends organismal lifespan when
    expressed in the intestinal stem cell lineages of the adult midgut under non-regenerative
    conditions. Notably, HRJDs enhance the proliferative activity of intestinal stem
    cells while maintaining their differentiation fidelity, ameliorating age-related
    decline in gut barrier functions.\r\n\r\nConclusions: These findings together
    suggest that the introduction of highly regenerative species-specific genes can
    improve stem cell functions and promote a healthy lifespan when expressed in aging
    animals."
acknowledgement: "We thank I. Miguel-Aliaga, N. Shinoda, M. Furuse, Y. Izumi, BDSC,
  Kyoto Stock Center, Drosophila Genomics Resource Center (DGRC), and Developmental
  Studies Hybridoma Bank (DSHB) for fly stocks and reagents.\r\nThis work was supported
  by JSPS/MEXT KAKENHI (grant numbers JP22J01430 to H.N., JP21H04774, JP23H04766,
  JP24H00567 to M.M., and JP17H06332, JP22H02762, JP23K18134, JP23H04696 to Y.N.),
  AMED-Aging (JP21gm5010001 to M.M.), AMED-PRIME (JP22gm6110025 to Y.N.), and Sadako
  O. Hirai Ban Award for Young Researchers (H.N.)"
article_number: '157'
article_processing_charge: Yes
article_type: original
author:
- first_name: Hiroki
  full_name: Nagai, Hiroki
  id: 608df3e6-e2ab-11ed-8890-c9318cec7da4
  last_name: Nagai
  orcid: 0000-0003-1671-9434
- first_name: Yuya
  full_name: Adachi, Yuya
  last_name: Adachi
- first_name: Tenki
  full_name: Nakasugi, Tenki
  last_name: Nakasugi
- first_name: Ema
  full_name: Takigawa, Ema
  last_name: Takigawa
- first_name: Junichiro
  full_name: Ui, Junichiro
  last_name: Ui
- first_name: Takashi
  full_name: Makino, Takashi
  last_name: Makino
- first_name: Masayuki
  full_name: Miura, Masayuki
  last_name: Miura
- first_name: Yu Ichiro
  full_name: Nakajima, Yu Ichiro
  last_name: Nakajima
citation:
  ama: NAGAI H, Adachi Y, Nakasugi T, et al. Highly regenerative species-specific
    genes improve age-associated features in the adult Drosophila midgut. <i>BMC Biology</i>.
    2024;22. doi:<a href="https://doi.org/10.1186/s12915-024-01956-4">10.1186/s12915-024-01956-4</a>
  apa: NAGAI, H., Adachi, Y., Nakasugi, T., Takigawa, E., Ui, J., Makino, T., … Nakajima,
    Y. I. (2024). Highly regenerative species-specific genes improve age-associated
    features in the adult Drosophila midgut. <i>BMC Biology</i>. Springer Nature.
    <a href="https://doi.org/10.1186/s12915-024-01956-4">https://doi.org/10.1186/s12915-024-01956-4</a>
  chicago: NAGAI, HIROKI, Yuya Adachi, Tenki Nakasugi, Ema Takigawa, Junichiro Ui,
    Takashi Makino, Masayuki Miura, and Yu Ichiro Nakajima. “Highly Regenerative Species-Specific
    Genes Improve Age-Associated Features in the Adult Drosophila Midgut.” <i>BMC
    Biology</i>. Springer Nature, 2024. <a href="https://doi.org/10.1186/s12915-024-01956-4">https://doi.org/10.1186/s12915-024-01956-4</a>.
  ieee: H. NAGAI <i>et al.</i>, “Highly regenerative species-specific genes improve
    age-associated features in the adult Drosophila midgut,” <i>BMC Biology</i>, vol.
    22. Springer Nature, 2024.
  ista: NAGAI H, Adachi Y, Nakasugi T, Takigawa E, Ui J, Makino T, Miura M, Nakajima
    YI. 2024. Highly regenerative species-specific genes improve age-associated features
    in the adult Drosophila midgut. BMC Biology. 22, 157.
  mla: NAGAI, HIROKI, et al. “Highly Regenerative Species-Specific Genes Improve Age-Associated
    Features in the Adult Drosophila Midgut.” <i>BMC Biology</i>, vol. 22, 157, Springer
    Nature, 2024, doi:<a href="https://doi.org/10.1186/s12915-024-01956-4">10.1186/s12915-024-01956-4</a>.
  short: H. NAGAI, Y. Adachi, T. Nakasugi, E. Takigawa, J. Ui, T. Makino, M. Miura,
    Y.I. Nakajima, BMC Biology 22 (2024).
date_created: 2024-08-11T22:01:11Z
date_published: 2024-08-02T00:00:00Z
date_updated: 2025-09-08T08:51:29Z
day: '02'
ddc:
- '570'
department:
- _id: XiFe
doi: 10.1186/s12915-024-01956-4
external_id:
  isi:
  - '001282893200001'
  pmid:
  - '39090637'
file:
- access_level: open_access
  checksum: 318759626ec83b13f909c82904393ef1
  content_type: application/pdf
  creator: dernst
  date_created: 2024-08-12T08:14:44Z
  date_updated: 2024-08-12T08:14:44Z
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  file_name: 2024_BMCBio_Nagai.pdf
  file_size: 3345718
  relation: main_file
  success: 1
file_date_updated: 2024-08-12T08:14:44Z
has_accepted_license: '1'
intvolume: '        22'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: BMC Biology
publication_identifier:
  eissn:
  - 1741-7007
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Highly regenerative species-specific genes improve age-associated features
  in the adult Drosophila midgut
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 22
year: '2024'
...