---
res:
  bibo_abstract:
  - Atopic dermatitis (AD) is the most common chronic inflammatory skin disease worldwide.
    AD is a highly complex disease with different subtypes. Many elements of AD pathophysiology
    have been described, but if/how they interact with each other or which mechanisms
    are important in which patients is still unclear. Langerhans cells (LCs) are antigen-presenting
    cells (APCs) in the epidermis. Depending on the context, they can act either pro-
    or anti-inflammatory. Many different studies have investigated LCs in the context
    of AD and found them to be connected to all major mechanisms of AD pathophysiology.
    As APCs, LCs recruit other immune cells and shape the immune response, especially
    adaptive immunity via polarization of T cells. As sentinel cells, LCs are primary
    sensors of the skin microbiome and are important for the decision of immunity
    versus tolerance. LCs are also involved with the integrity of the skin barrier
    by influencing tight junctions. Finally, LCs are important cells in the neuro-immune
    crosstalk in the skin. In this review, we provide an overview about the many different
    roles of LCs in AD. Understanding LCs might bring us closer to a more complete
    understanding of this highly complex disease. Potentially, modulating LCs might
    offer new options for targeted therapies for AD patients.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Yi
      foaf_name: Pan, Yi
      foaf_surname: Pan
  - foaf_Person:
      foaf_givenName: Mathias
      foaf_name: Hochgerner, Mathias
      foaf_surname: Hochgerner
  - foaf_Person:
      foaf_givenName: Malgorzata Anna
      foaf_name: Cichon, Malgorzata Anna
      foaf_surname: Cichon
      foaf_workInfoHomepage: http://www.librecat.org/personId=d63197a3-c188-11ed-9387-8d33a3f13871
  - foaf_Person:
      foaf_givenName: Theresa
      foaf_name: Benezeder, Theresa
      foaf_surname: Benezeder
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Bieber, Thomas
      foaf_surname: Bieber
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Wolf, Peter
      foaf_surname: Wolf
  bibo_doi: 10.1111/jdv.20291
  bibo_issue: '2'
  bibo_volume: 39
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001292894900001
  dct_isPartOf:
  - http://id.crossref.org/issn/0926-9959
  - http://id.crossref.org/issn/1468-3083
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: 'Langerhans cells: Central players in the pathophysiology of atopic dermatitis@'
  fabio_hasPubmedId: '39157943'
...